Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in Alzheimer's Disease and Rosacea

    November 2021 in “ Frontiers in Immunology ”
    Huaxiong Zhang, Yiya Zhang, Yangfan Li, Yaling Wang, Yan Sha, San Xu, Zhili Deng, Xinling Yang, Hongfu Xie, Ji Li
    Image of study
    TLDR Melatonin could be an effective treatment for Alzheimer's Disease and rosacea.
    The study used bioinformatics and network pharmacology to investigate the therapeutic role of Melatonin (MLT) in Alzheimer's Disease (AD) and rosacea, a chronic skin disease. The research identified 747 genes shared between AD and rosacea, and 24 key transcription factors (TFs) involved in inflammation, blood vessel development, and apoptosis. Three potential drugs were identified for treating AD and rosacea, with MLT being the most promising. In experiments, MLT significantly improved rosacea-like symptoms in mice, reduced inflammation, and suppressed blood vessel formation. The study concluded that MLT could be an effective treatment for both AD and rosacea.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 251 results

      community Exploring Bryan Johnson's Hair Routine In Detail

      in Research/Science  65 upvotes 10 months ago
      Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

      community Is anyone using melatonin for hair loss?

      in Research/Science  9 upvotes 5 months ago
      Melatonin is being discussed as a potential treatment for hair loss, with questions about its effectiveness and whether it should be used topically or orally. No specific conclusions or personal experiences were shared.

      community Melatonin options for Europe??? *Retrograde Alopecia*

      in Product  3 upvotes 6 months ago
      A user is considering using melatonin for hair recovery on the side and neck area but is unsure about the best options in Europe and whether a dietary supplement form can be applied to the scalp. They found a product but are hesitant and seeking opinions on its use for alopecia.

      community Optimal dose for topical Melatonin

      in Treatment  6 upvotes 1 year ago
      The conversation is about finding the optimal concentration of topical melatonin for hair loss treatment. The user is considering making their own solution and is unsure whether a higher concentration is more effective for deactivating prolactin receptors.

      community Compounding Topical Melatonin at Home

      in Treatment  7 upvotes 3 years ago
      Melatonin at a 0.0033% concentration shows results for hair loss when used topically. A user is discussing how to replicate this by adding 2mg of Melatonin to 60ml of Minoxidil solution.

    Similar Research

    5 / 1000+ results