TLDR Activating Nrf2 can help protect against hearing loss.
The document reviewed the role of the Nrf2 transcription factor in mitigating hearing loss by regulating oxidative stress-inducible genes. It highlighted that Nrf2 activation could protect hair cells from damage caused by noise, ototoxic drugs, and aging. Various compounds, such as ebselen, ferulic acid, and curcumin, were shown to activate Nrf2, reducing oxidative damage and preserving hearing function. While Nrf2-targeting drugs showed promise in cell and animal studies, their clinical application remained limited, necessitating further research to optimize drug dosages, administration routes, and understand Nrf2 interactions with other transcription factors.
21 citations,
October 2017 in “Cell death and disease” Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.
4 citations,
August 2023 in “Biomedicine & Pharmacotherapy” Ivacaftor can protect against noise-induced hearing loss by reducing oxidative stress.
5 citations,
July 2021 in “Basic & Clinical Pharmacology & Toxicology” Melatonin may protect ear cells from damage caused by nicotine.
1 citations,
March 2024 in “Journal of Cellular and Molecular Medicine” 4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.
21 citations,
October 2017 in “Cell death and disease” Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.
5 citations,
November 2022 in “Molecular Neurobiology” Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.
