Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, activation of c-MycER in adult mouse epidermis rapidly induced proliferation and disrupted keratinocyte differentiation, causing changes similar to precancerous lesions, which regressed once c-MycER was deactivated.

This review discusses how dehydroepiandrosterone (DHEA) may exert its biological effects through multiple receptors and reports no new clinical results.

This study found that GALT5 and GALT2 are redundant enzymes essential for O-glycosylation of AGPs, with mutations leading to significant growth and development defects in plants.

This study identifies specific molecular components involved in the intracellular trafficking of LGR5, revealing mechanisms that differ from typical GPCR recycling processes.

This study found that a topical gel formulation containing rice water demonstrated in vitro antioxidant activity and elastase inhibition, suggesting its potential as an anti-aging skincare ingredient.

The researchers found that plant extracts from Papaver rhoeas L., Clitoria ternatea L., and Carthamus tinctorius L. are effective natural cosmetic dyes, offering intense and stable colors without cytotoxicity.

This study found that illness perception, as measured by the Revised Illness Perception Questionnaire, was significantly associated with health-related quality of life in patients with primary cutaneous T- and B-cell lymphomas.

This article provides an overview of microneedle technology for transcutaneous drug delivery, discussing microneedle designs, materials, and activation methods that enhance drug stability and regulated release, and outlines considerations for their successful clinical implementation, such as biocompatibility and production cost.

This review highlights how social, environmental, and biological factors combine to increase COVID-19 risks in the African American community, emphasizing the need to understand these complex disparities; it reports no new results.

This study found that mesenchymal progenitor cells from human hair roots seeded onto polymer scaffolds stimulated the production of mineralized proteins, enhancing bone-like structures, with optimal results at a pore size of 35 µm.

This study suggests that microvascular damage and platelet deregulation may persist in ulcerative colitis patients even during remission, remaining as disease-associated molecular signatures.

This review explores how adaptive changes in cerebellar and vestibular subsystems may contribute to balance control, noting cellular mechanisms involved, but presents no new clinical findings.

In this study, researchers demonstrated that follicular tight junctions in porcine skin form a barrier to nanoparticle penetration, particularly in upper regions, which supports its use as a model for human skin.

This study explored the development of polymeric nanoparticles for topical spironolactone delivery, finding that larger nanoparticles (180 nm) enhanced drug targeting to hair follicles significantly more than smaller ones or non-nanoparticle formulations, offering promise for safer acne and alopecia treatments.

This study found that overexpressing the 14-3-3σ protein in transgenic mice reduced keratinocyte proliferation and migration, leading to thinner epidermis and fewer hair follicles due to IGF-1 pathway inhibition.

This review examines the use of tadalafil and finasteride as a combined therapy for BPH, suggesting it may effectively reduce treatment-related sexual adverse events and improve symptom relief.

This study found that men with early-onset androgenic alopecia had a higher prevalence of cardiovascular risk factors, indicating that early screening for metabolic syndrome may be beneficial in this population.

This study found that stabilizing β-catenin in a specific mouse model led to temporarily increased hair density but ultimately accelerated hair follicle aging and hair thinning.

In this study, researchers found that human ovaries at different life stages biosynthesize both canonical and non-canonical steroid hormones, with fetal ovaries showing higher enzyme activity related to estradiol and testosterone conversion compared to adult tissues.

This review discusses the use of microbial biosurfactants as a safer alternative to chemical surfactants in cosmetics due to their antibacterial, moisturizing, and low toxicity properties, but it reports no new clinical findings.

This study found that Gelidium corneum, a type of red seaweed, may serve as a promising source of bioactive compounds for skin health, showing photoprotective and healing properties in vitro and antioxidant and stability benefits in vivo when used in dermocosmetic formulations.

This review examines the skin manifestations of various endocrine disorders, highlighting their underlying pathophysiology and impact on an individual's health and quality of life, without reporting new research findings.

This study reviews the use of nanofat in facial rejuvenation and cosmetic surgery, highlighting its potential for improving skin appearance and treating conditions like wrinkles and acne scars, yet emphasizes the need for further research into its long-term efficacy and safety.

This article discusses the potential role of probiotics and synbiotics in managing hirsutism through insulin resistance but reports no new clinical results, calling for further research.

This study found that 11-oxygenated androgens were higher in women with PCOS compared to those with idiopathic hirsutism, with no difference from controls, and higher Bisphenol A levels in obese women with PCOS may worsen metabolic issues.

This review highlights the possible impact of side effects from endocrine therapy on quality of life, emphasizing that these can lead to poor adherence and early treatment discontinuation in patients with hormone receptor positive early breast cancer, potentially worsening survival outcomes.

This study developed and validated a highly sensitive LC-MS/MS method for detecting multiple steroid hormones in urine and serum/plasma, demonstrating its potential for use in large-scale biomonitoring studies.

This study investigated the effects of wool-derived hydrolysed keratin peptides on relaxed textured hair and found that mid- and high-molecular weight peptides improved mechanical strength and reduced breakage in different humidity conditions.