The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women

September 2024 in “ International Journal of Molecular Sciences ”

Jana Vítků, Anezka Varausova, Tereza Škodová, Lucie Kolátorová, Michala Vosátková, Josef Včelák, Jana Vrbíková, M Simková, Michaela Svojtková

11-oxygenated androgens endocrine disruptors polycystic ovary syndrome idiopathic hirsutism bisphenol A androgen excess disorders PCOS IH BPA

Studysummary This study found that 11-oxygenated androgens were higher in women with PCOS compared to those with idiopathic hirsutism, with no difference from controls, and higher Bisphenol A levels in obese women with PCOS may worsen metabolic issues. Our plain-language summary of this paper — not a Tressless recommendation.

This study examines the role of 11-oxygenated androgens and endocrine disruptors in androgen excess disorders, specifically polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH), in women. Involving 51 participants, the research found that women with PCOS had higher levels of 11-oxygenated androgens compared to those with IH and controls, while IH patients had lower levels than controls. Elevated bisphenol A (BPA) levels in obese women with PCOS suggest a potential exacerbation of metabolic issues, though BPA did not influence IH. The study highlights significant correlations between certain androgens and metabolic parameters, suggesting that 11-oxygenated androgens could be significant in diagnosing hyperandrogenic disorders, and that BPA might contribute to metabolic abnormalities in PCOS.

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Research cited in this study

8 / 8 results

research 11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome

9 citations , March 2022 in “Journal of the Endocrine Society”

This study found that testosterone more accurately predicts PCOS diagnosis than 11-oxyandrogens, which were linked with hirsutism severity and showed varying responses to contraceptive and metformin treatments.

research Distribution of Body Hair in Young Australian Women and Associations With Serum Androgen Concentrations

12 citations , February 2020 in “The Journal of Clinical Endocrinology & Metabolism”

This study found that a self-assessed modified Ferriman-Gallwey score of 10 or higher indicates excess body hair, and suggests androstenedione measurement should accompany testosterone when evaluating hyperandrogenism.

research Androgens in Women: Critical Evaluation of Methods for Their Determination in Diagnosing Endocrine Disorders

10 citations , November 2018 in “Physiological Research”

This review examines the methods and challenges in androgen laboratory diagnostics, discussing their advantages, limitations, and evolution; it presents no new experimental results.

research Update on Idiopathic Hirsutism: Diagnosis and Treatment

6 citations , July 2013 in “Acta Clinica Belgica”

This review discusses idiopathic hirsutism and suggests that combination treatment, including androgen suppression and cosmetic methods, is most effective, but notes that its pathogenesis remains unclear.

research Diagnosis of Hyperandrogenism: Clinical Criteria

85 citations , June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism”

This review outlines the challenges in diagnosing hyperandrogenism in women, focusing on its manifestations like hirsutism, acne, and virilization, but provides no new results.

research Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred Because of Clinical Hyperandrogenism

352 citations , January 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This study reported that classic anovulatory PCOS was the most common androgen excess disorder, followed by mild ovulatory PCOS and idiopathic hyperandrogenism, among patients evaluated for clinical hyperandrogenism.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, polycystic ovary syndrome was the most prevalent cause of androgen excess, and suppressive hormonal therapy improved hirsutism, menstrual dysfunction, and acne in most patients, though side effects were common.

research Idiopathic Hirsutism: Androgen Role and Treatment Options

47 citations , August 2000 in “Endocrine Reviews”

This review discusses idiopathic hirsutism, potential underlying mechanisms, and various therapeutic approaches without providing new clinical results, and emphasizes the need for further research on well-defined patient groups.