The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women

September 2024 in “ International Journal of Molecular Sciences ”

Jana Vítků, Anezka Varausova, Tereza Škodová, Lucie Kolátorová, Michala Vosátková, Josef Včelák, Jana Vrbíková, M Simková, Michaela Svojtková

11-oxygenated androgens endocrine disruptors polycystic ovary syndrome idiopathic hirsutism bisphenol A androgen excess disorders PCOS IH BPA

TLDR PCOS involves high 11-oxygenated androgens and BPA may worsen it, while IH is not inflammatory.

This study investigated the role of 11-oxygenated androgens and endocrine disruptors in women with polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH). The study included 51 women: 10 non-obese with PCOS, 12 with IH, 20 controls, and 9 obese with PCOS. Results showed higher 11-oxygenated androgen levels in women with PCOS compared to IH and controls, while IH had lower levels than controls. Bisphenol A (BPA) levels were elevated in obese women with PCOS, potentially worsening metabolic issues, but BPA did not appear to influence IH. The study confirmed PCOS as a multiendocrine disorder and found no evidence of IH being an inflammatory condition.

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