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research Early-Onset Androgenetic Alopecia and Endocrine Disruptors
Endocrine disruptors may cause early hair loss.
research Mixture Effects of Endocrine Disrupting Compounds In Vitro
The study investigated the additive effects of four different equi-molar mixtures of endocrine disrupting compounds on the androgen receptor (AR) using the concentration addition model. It found that additive effects could be predicted for mixtures affecting the AR, such as flutamide, procymidone, and vinclozolin, as well as for mixtures with compounds both affecting and not affecting the AR, like finasteride and prochloraz. However, a paraben mixture showed antagonistic effects on the AR, which could not be predicted under the assumption of additivity. For a mixture of azole fungicides, the AR antagonistic effects were close to predicted, but the inhibition of oestradiol production was over-estimated. The study concluded that weak endocrine disruptors, like parabens and azole fungicides, can have significant combination effects in mixtures, which should be considered in regulatory risk assessments to avoid underestimating the risks of exposure.
research Evaluation of the Rodent Hershberger Assay Using Three Reference Endocrine Disruptors (Androgen and Antiandrogens)
The assay effectively detects hormonal activity of certain chemicals.
research Disorders Linked to Insufficient Androgen Action in Male Children
Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.
research Apocrine Sweat Gland Obstruction by Antiperspirants Allowing Transdermal Absorption of Cutaneous Generated Hormones and Pheromones as a Link to the Observed Incidence Rates of Breast and Prostate Cancer in the 20th Century
The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.
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5 / 178 resultscommunity Do you think people of previous generations had better hair? What changed?
Hair loss is less common now due to accessible treatments like finasteride, minoxidil, and hair transplants. Improved hair care, skincare, and lifestyle changes contribute to people looking younger today.
community Is this real chat? Finasteride -> fountain of youth and longevity drug?
Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.
community Yes your lifestyle and diet has its role in hair loss.
Diet and lifestyle changes can reduce hair shedding but won't regrow hair lost to genetic male pattern baldness. Treatments like finasteride and dutasteride are necessary for significant hair regrowth.
community Haunting study is making me considering cycling fin/dut
Concerns about the long-term effects of dutasteride and finasteride on fertility, with discussions on cycling these medications to mitigate risks. The conversation highlights skepticism about study methodologies and the importance of weighing treatment risks against potential fertility issues.
community When Life Starts Taking Your Hair... And Then Your Confidence: A 25-Year-Old’s Battle with Hair Loss
A 25-year-old discusses hair loss and its impact on confidence, considering treatments like finasteride and minoxidil. Recommendations include these medications and lifestyle changes to manage hair loss.