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Apocrine Sweat Gland Obstruction by Antiperspirants Allowing Transdermal Absorption of Cutaneous Generated Hormones and Pheromones as a Link to the Observed Incidence Rates of Breast and Prostate Cancer in the 20th Century

research Apocrine sweat gland obstruction by antiperspirants allowing transdermal absorption of cutaneous generated hormones and pheromones as a link to the observed incidence rates of breast and prostate cancer in the 20th century

18 citations , March 2009 in “Medical Hypotheses”

This review discusses the potential link between long-term transdermal exposure to sex hormones from antiperspirants and increased breast and prostate cancer rates, calling for further research to confirm this theory.

research Early-onset androgenetic alopecia and endocrine disruptors

January 2011 in “Journal of biological research”

This review discusses potential links between early-onset androgenetic alopecia and exposure to endocrine disruptors in adolescents, but reports no clinical results; the authors suggest further investigation.

research A preliminary study on the relationship between environmental endocrine disruptors and precocious puberty in girls

16 citations , June 2022 in “Journal of Pediatric Endocrinology and Metabolism”

This study found an association between higher phthalate exposure and increased incidence of precocious puberty in girls, suggesting a need to reduce children's exposure to these endocrine disruptors.

research Mixture effects of endocrine disrupting compounds in vitro

108 citations , January 2010 in “International Journal of Andrology”

This study concluded that mixtures of weak endocrine disruptors, such as parabens and azole fungicides, can produce combination effects that should be considered in regulatory risk assessments to avoid underestimating potential risks.

Women's Skin Throughout Lifetime: Hormonal Impact and Disorders

research Women's Skin throughout Lifetime

5 citations , January 2014 in “BioMed Research International”

This collection of papers reviews recent research on women's skin, focusing on hormonal influences, environmental impacts, and specific skin disorders, with no new clinical results reported.

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Community Join

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community Can rosemary oil cause gynaecomastia?

in Microneedling 2 years ago

A user is concerned that using rosemary oil after microneedling might cause gynaecomastia due to increased absorption and potential DHT blocking. Other users believe rosemary oil is unlikely to affect hormones or cause gynaecomastia.

community Is it me or are people losing their hair very young now?

in Finasteride/Dutasteride 143 upvotes 6 years ago

People notice more young individuals experiencing hair loss and discuss possible reasons, such as diet, hormones, and stress. Some treatments mentioned include finasteride, dutasteride, and minoxidil.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Two months of minoxidil 5mg only!

in Progress Pictures 197 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically the use of minoxidil and the potential addition of finasteride. The user has seen some progress with minoxidil but is hesitant about finasteride due to possible side effects, while others suggest combining both for better long-term results.

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Centella

Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? Applying Estradiol directly to the scalp may help with hormone-related hair thinning.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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