11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome

    March 2022 in “ Journal of the Endocrine Society ”
    Anya Taylor, Meredith A Ware, Emily Breslow, Laura Pyle, Cameron Severn, Kristen J. Nadeau, Christine L. Chan, Megan M. Kelsey, Melanie Cree-Green
    Image of study
    TLDR Girls with PCOS have higher levels of certain androgens, which are linked to excess hair growth, but these androgens don't help diagnose PCOS.
    The study "11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome" involved 200 adolescent females, including 115 with untreated Polycystic Ovary Syndrome (PCOS), 70 controls, and 15 with PCOS and obesity treated with either combined oral contraceptive pills (COCPs) or metformin. The research found that untreated girls with PCOS had higher levels of 11-Hydroxyandrostenedione (11-OHA4) and 11-hydroxytestosterone (11-OHT) compared to controls. However, testosterone was a better predictor of PCOS status than 11-oxyandrogens. All three 11-oxyandrogens correlated with hirsutism severity in untreated PCOS patients. COCP treatment lowered 11-Ketotestosterone (11-KT) and testosterone levels, while metformin treatment had no effect on 11-oxyandrogens, although it did lower testosterone. The study concluded that while 11-oxyandrogens do not aid in diagnosing PCOS, they are related to excess hair growth. Further research is needed to determine their relationship with metabolic outcomes and the clinical utility of measuring these androgens in PCOS.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 12 results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 2 months ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community Why balding gets worse in every generation?

      in Chat  81 upvotes 5 months ago
      Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

    Related Research

    1 / 1 results