The Profile of Steroid Hormones in Human Fetal and Adult Ovaries

May 2024 in “ Reproductive Biology and Endocrinology ”

P. Vazakidou, Sara Evangelista, Tianyi Li, Laetitia L. Lecante, Kristine Rosenberg, Jacco Koekkoek, Andres Salumets, Agne Velthut‐Meikas, Pauliina Damdimopoulou, Séverine Mazaud‐Guittot, Paul Fowler, P.E.G. Leonards, Majorie B.M. van Duursen

steroid hormones endocrine-disrupting chemicals ovarian development ovarian function infertility treatment follicular fluid LC-MS/MS progestogen corticosteroids steroidogenesis hypothalamic-pituitary-gonad axis hypothalamic-pituitary-adrenal axis EDCs infertility hormone profiles hormone synthesis

TLDR Fetal ovaries produce different hormones than adult ovaries, and endocrine-disrupting chemicals may affect this process.

The study examines steroid hormone profiles in human fetal and adult ovaries, focusing on the effects of endocrine-disrupting chemicals (EDCs) on ovarian development and function. It involved 8 fetal and 13 adult ovarian samples, as well as 148 women undergoing infertility treatment, with 14 follicular fluid samples analyzed. The research developed an LC-MS/MS method to quantify 21 steroid hormones, revealing distinct profiles between fetal and adult tissues. Fetal ovaries showed high progestogen release, while adult tissues had higher overall steroid hormone release. The study highlights the potential of fetal ovaries to synthesize various hormones, including corticosteroids, and underscores the need for better regulation of EDCs due to their unclear impact on ovarian steroidogenesis and female fertility. Limitations include a small sample size and lack of hypothalamic-pituitary-gonad/adrenal axis involvement in cultures.

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research Local Therapy of Androgenetic Alopecia with 17 Alpha-Estradiol: A Controlled, Randomized Double-Blind Study

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research Local Therapy of Androgenetic Alopecia with 17α-Estradiol

54 citations , January 1980 in “Dermatology”

17α-estradiol lotion can reduce hair loss but doesn't promote new hair growth.

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The Profile of Steroid Hormones in Human Fetal and Adult Ovaries

Research cited in this study

research Local Therapy of Androgenetic Alopecia with 17 Alpha-Estradiol: A Controlled, Randomized Double-Blind Study

research Local Therapy of Androgenetic Alopecia with 17α-Estradiol

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