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research The profile of steroid hormones in human fetal and adult ovaries

11 citations , May 2024 in “Reproductive Biology and Endocrinology”

In this study, researchers found that human ovaries at different life stages biosynthesize both canonical and non-canonical steroid hormones, with fetal ovaries showing higher enzyme activity related to estradiol and testosterone conversion compared to adult tissues.

research Effects Of Hormone Therapy On The Laboratory Profile Of Transgender People: A Scoping Review

January 2021 in “Open MIND”

This scoping review aims to explore the impact of hormone therapy on the laboratory profiles of transgender people, identify evidence, and highlight literature gaps, particularly in developing countries.

research Differential relationships between chronic hormone profiles in pregnancy and maternal investment in rhesus monkey mothers with hair loss in the neonatal period

7 citations , October 2015 in “American Journal of Primatology”

The researchers observed that pregnancy in rhesus monkeys was associated with an increased incidence of hair loss, though the underlying reasons remain unclear.

research Expression Profiles of Reproduction- and Thyroid Hormone-Related Transcripts in the Brains of Chemically-Induced Intersex Frogs

24 citations , January 2011 in “Sexual Development”

This study observed that chemically-induced intersex frogs displayed altered brain mRNA profiles, with finasteride increasing certain hormone-related gene expressions and fadrozole reducing aromatase activity without affecting gene transcript levels.

research Reproductive profiles, androgen hormones and energetic status of oligomenorrheic exercising women

January 2008 in “TSpace”

This study found that premenopausal exercising women with oligomenorrhea had lower triiodothyronine levels and truncal fat percentage compared to other groups, suggesting distinct energetic and reproductive profiles.

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community Hormone tests to decide on oral fin

4 upvotes 1 year ago

The conversation discusses starting low-dose oral finasteride for hair loss, considering hormone levels and potential side effects like gynecomastia. Suggestions include using DIM for estradiol, vitamin B6 for prolactin, and lifestyle changes to optimize hormone profiles before starting treatment.

community What is the goal of these people?

in Chat 30 upvotes 5 months ago

The conversation discusses the use of finasteride for hair loss treatment and addresses misconceptions about its use in hormone replacement therapy. It also touches on the safety and long-term effects of finasteride, with some users expressing skepticism and others defending its safety profile.

community Did Dutasteride change how you look physically? your facial profile such as skin thickness, fat distribution or softness?

in Finasteride/Dutasteride 51 upvotes 1 year ago

Dutasteride and finasteride can cause changes in physical appearance, like more feminine features and increased water retention. Users report side effects such as reduced libido, weight gain, and improved skin clarity, while some notice no significant changes.

community Hairloss - what hormones to check?

9 upvotes 2 years ago

The user is concerned about hair loss despite using oral finasteride, oral minoxidil, and topical minoxidil. They are seeking advice on additional blood tests to identify potential causes.

community Can your hormonal profile "readjust" during long term Finasteride use?

in Finasteride/Dutasteride 5 upvotes 4 months ago

The user experienced a decrease in libido after long-term use of Finasteride and wonders if it's related to the medication. Responses suggest that hormonal changes and libido fluctuations are normal and may not be solely due to Finasteride.

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Learn

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learn HMI-115

Is HMI-115 considered a safe option, or does it have strong side effects? HMI-115 is an experimental injected antibody, not a hormone blocker: the one published trial (in endometriosis) reported an acceptable 12-week tolerability profile with no treatment-related serious adverse events, and no peer-reviewed safety data exists for its use in hair loss.

learn sh-Polypeptide-7

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

learn Overview

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Centella

Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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