Bone-Forming Cells with Pronounced Spread into the Third Dimension in Polymer Scaffolds Fabricated by Two-Photon Polymerization

    December 2016 in “ Journal of Biomedical Materials Research Part A ”
    J. Heitz, Cristina Plamadeala, Moritz Wiesbauer, Paul J. Freudenthaler, Richard Wollhofen, Jaroslaw Jacak, Thomas A. Klar, B. Magnus, D. Köstner, Agnes Weth, Werner Baumgärtner, Rainer Marksteiner
    TLDR Bone-forming cells grow well in 3D polymer scaffolds with 35 µm pores.
    The study demonstrated that bone-forming cells from human hair roots, when seeded onto polymer scaffolds fabricated using two-photon polymerization, exhibited significant three-dimensional spreading and differentiation into osteoblast-like cells. The optimal scaffold pore size was 35 µm, which led to high production of calcium-binding proteins like collagen type I and increased activation of the actin cytoskeleton. This approach showed potential for bone tissue engineering, particularly in dental applications, by creating a composite material of polymer, bone-forming cells, and calcium minerals.
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