9 citations
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May 2022 in “Drugs in Context” This report describes the successful use of sonidegib in treating two cases of locally advanced basal cell carcinoma, leading to remission in both instances, and reducing lesions in a patient with Gorlin syndrome, while noting mild side effects consistent with the drug's known profile.
9 citations
,
October 2021 in “Biological and Pharmaceutical Bulletin” This study found that mupirocin nanoparticle-loaded hydrogel was safe and more effective for healing burn wounds in rats compared to mupirocin ointment, showing promise for future clinical trials.
9 citations
,
May 2019 in “Experimental Cell Research” This study found that Hedgehog signaling likely contributes to cervical carcinogenesis, and while itraconazole reduced growth in mice, it did so through pathways other than inhibiting Hedgehog signaling.
9 citations
,
November 2018 in “Drug Discovery Today” This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.
8 citations
,
January 2021 in “Smart materials in medicine” This study found that a newly constructed composite hydrogel dressing, made from silk fibroin, chitosan, and halloysite, promoted hair follicle neogenesis, angiogenesis tissue regeneration, and scar reduction.
8 citations
,
January 2020 in “Biomaterials Science” In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.
8 citations
,
April 2009 in “International journal of oncology” This study found that bulge-derived keratinocytes from human follicles were more resistant to differentiation compared to epidermal keratinocytes, possibly due to WIF-1 involvement.
6 citations
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June 2019 in “Biotechnology Letters” Gene therapy shows promise for improving wound healing, but more research is needed for human use.
6 citations
,
November 2018 in “Histochemistry and Cell Biology” This study observed that gerbils exhibit a different wound healing mechanism compared to mice, with lower TGF-B1 expression and distinct tissue responses, yet achieve similar healing outcomes.
6 citations
,
January 2016 in “Journal of Stem Cell Research & Therapy” This study found that suppressing Jagged1 in epidermal stem cells disrupted Notch signaling and resulted in poor-quality wound healing, suggesting a potential therapeutic target for improving wound repair.
5 citations
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February 2024 in “Frontiers in bioengineering and biotechnology” This research review outlines the challenges of diabetic wounds, such as diabetic foot ulcers, and examines the potential of electrospinning nanofiber scaffolds to improve healing by promoting tissue formation, allowing drug release, and enhancing specific wound healing properties.
5 citations
,
May 2020 in “Life science alliance” This study found that epidermal-specific deletion of integrin α3β1 significantly reduces papilloma formation in a skin carcinogenesis model by modulating HB stem cell behavior and CCN2 expression.
5 citations
,
March 2020 in “Cell and Tissue Banking” This study found that injecting a mixture of epidermal stem cells and dermal papilla cells can induce hair follicle regeneration and well-ordered epidermis formation in mice.
5 citations
,
March 2017 in “Cell and Tissue Banking” In this study, noncultured autologous skin cells prepared using a tissue homogenizer significantly improved burn wound healing in rats compared to a control treatment.
4 citations
,
January 2026 in “Cell Discovery” This study introduced the concept of spatiotemporal clocks to understand how different phases of mammalian wound healing are coordinated, with a focus on the spatial domains and oscillatory molecular signals involved, while highlighting the potential for regenerative therapeutic strategies.
4 citations
,
January 2025 in “Journal of Materials Chemistry B” In this study, researchers developed a multifunctional, injectable hydrogel that adapts to irregularly shaped wounds, enhances healing, and shows potential antibacterial activity without significant toxicity, suggesting promise for treating chronic wounds.
4 citations
,
November 2022 in “Journal of clinical and translational research” This systematic review found that chitosan-based wound therapy may accelerate wound healing by reducing inflammation and modulating immune response, but notes limited clinical trials to date.
3 citations
,
February 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that exposing adult esophageal epithelial cells to skin stroma can induce them to transition toward a hair follicle identity, with HIF1a playing a crucial role in this conversion process.
3 citations
,
December 2019 in “Journal of Cosmetic and Laser Therapy” This study found that plasma rich in growth factors showed promising results for increasing hair number and thickness in androgenic alopecia patients, with better outcomes after multiple injections.
3 citations
,
April 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, beta-caryophyllene enhanced wound healing in female mice by improving re-epithelialization, cell proliferation, and cell migration, suggesting potential benefits of essential oil compounds in inflammation reduction.
3 citations
,
February 2013 in “Journal of Medicinal Plants Research” This study found that both crude Spirulina extract and C-phycocyanin showed similar effects on keratinocyte proliferation and wound healing, with C-phycocyanin performing better in tissue regeneration in vivo on the 7th day.
3 citations
,
January 2000 This chapter discusses various substances and therapies for dermatological applications, including heliotherapy, UVB, khellin, and others, but reports no new research findings.
3 citations
,
June 1983 in “Archives of Dermatology” This article discusses the effectiveness of adrenal cortex compounds E and F in treating connective tissue disorders like rheumatoid arthritis and lupus erythematosus, but it reports no new clinical results.
2 citations
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October 2025 in “Journal of Materials Science Materials in Medicine” In this study, researchers developed a novel zinc oxide nanoflower-infused nanocomposite that demonstrated promising results in accelerating wound healing in a murine model, with enhanced angiogenesis, reduced inflammation, and improved collagen deposition compared to a control group.
2 citations
,
November 2023 in “International Journal for Research in Applied Science and Engineering Technology” This review explores various tissue regeneration technologies, highlighting how skin substitutes have significantly improved healing success rates for burn injuries, and examines cell-based therapies aimed at reducing scar formation and improving burn management.
2 citations
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September 2023 in “Scientific reports” This study reports that zinc oxide or silver nanoparticles capped with vitamin A or E, incorporated into wheat gluten films, showed significant potential in promoting burn wound healing in mice by facilitating wound contraction, re-epithelialization, and collagen deposition, while also exhibiting antioxidant and antibacterial properties.
2 citations
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February 2023 in “Research Square (Research Square)” In this study, a newly engineered scaffold, PADM-MX-Ag-Si@Dox, demonstrated potential as a multifunctional biomaterial for postoperative melanoma treatment by controlling drug release, enhancing wound healing, and enabling real-time tumor surveillance through temperature, pH, and electrical stimuli.
2 citations
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December 2021 in “World journal of dentistry” In this study, Cocos nucifera (coconut) oil's antimicrobial properties showed effectiveness against Candida albicans and Streptococcus in an in vitro biofilm model, and its lauric acid content may reduce plaque adhesion and support oral health.
2 citations
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January 2020 in “Libri Oncologici Croatian Journal of Oncology” In this study, PRP injections into the muscular layer of rabbits' intestinal walls improved anastomosis regeneration with less adhesion compared to PRP soaking, though further research is needed to determine the best application method.
2 citations
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April 2009 in “Bulletin of Experimental Biology and Medicine” Flamena, a liposomal mix, helps skin heal better after a chemical burn.