Nature-Skin-Based Multi-Responsive Controlled-Release Electroactive Scaffolds for Integrated Melanoma Postoperative Relapse Prevention and Wound Therapy
February 2023
in “
Research Square (Research Square)
”
TLDR The scaffold effectively prevents melanoma relapse and aids wound healing.
The study presents an innovative electroactive scaffold, PADM-MX-Ag-Si@Dox, designed for integrated melanoma postoperative relapse prevention and wound therapy. This scaffold combines porcine dermal matrix, MXene nanosheets, silver nanowires, and drug-loading microspheres to enable controlled release of Doxorubicin (Dox) in response to temperature, pH, and electrical stimulation. The electrical stimulation not only facilitates the release of the anticancer drug but also enhances wound healing. The scaffold exhibits strong antimicrobial and electrophysiological properties, supporting wound healing and real-time tumor surveillance. Both in vitro and in vivo experiments confirm the scaffold's effectiveness in preventing melanoma relapse and promoting wound healing, offering a promising strategy for postoperative cancer treatment and precision medical care.
