35 citations
,
November 2020 in “Experimental Dermatology” This study found that upper wound fibroblasts are crucial for hair follicle regeneration during wound healing and suggests that these cells, along with papillary fibroblasts, migrate within the wound.
33 citations
,
September 2016 in “Lasers in Surgery and Medicine” In this review, the authors report that fractional resurfacing can be a safe and effective technique for treating scars and promoting photorejuvenation in Asian skin, though it requires cautious use to minimize risks like post-inflammatory hyperpigmentation and rebound melasma.
31 citations
,
July 2017 in “Clinical Science” This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.
29 citations
,
November 2014 in “Experimental Dermatology” This study found that α-MSH administration before skin wounding in adult mice reduced inflammation and scar area, suggesting a potential pathway to more regenerative healing.
28 citations
,
October 2019 in “Seminars in Cell & Developmental Biology” This article discusses the advances in understanding wound-induced hair follicle neogenesis (WIHN) and highlights the roles of specific signaling pathways and cellular plasticity, noting no clinical results but suggesting potential areas for further research.
28 citations
,
March 2017 in “African Journal of Traditional Complementary and Alternative Medicines” This study found that linseed oil, rich in flavonoids and terpenoids, significantly improved burn wound healing in terms of faster contraction, reduced inflammation, and enhanced tissue regeneration compared to other treatments, without adverse effects.
28 citations
,
February 2014 in “PLoS ONE” This study reports that transplantation of an ESCs-collagen-chitin biomimetic membrane leads to successful in situ skin regeneration, including hair follicle cell proliferation and formation of dermatoglyphs, in nude mice with full-thickness skin defects.
24 citations
,
November 2021 in “PLoS ONE” In this study, fractional laser treatment was observed to reverse age-related gene expression changes in skin and enhance dermal remodeling, further improved by multiple treatments.
24 citations
,
January 2019 in “Science China Life Sciences” Chitosan/LiCl composite scaffolds help heal deep skin wounds better.
24 citations
,
May 2016 in “Stem Cell Reviews and Reports” This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.
23 citations
,
September 2015 in “International Journal of Molecular Medicine” This study found that the activation of ER‑β increased keratinocyte proliferation and gene expression related to epidermal regeneration, enhancing wound healing in both cell models and rats.
22 citations
,
January 2017 in “Advanced Healthcare Materials” This study found that thermoresponsive hydrogels can maintain mechanical memory in fibroblasts, enhancing wound healing compared to traditional trypsinized methods.
20 citations
,
September 2019 in “South African Journal of Botany” This study found that Teucrium polium L. subsp. geyrii Maire extract demonstrated a large safety margin in acute and subacute toxicity tests on mice and significantly enhanced wound healing in rats, especially with callus extract, by improving cell proliferation and wound contraction.
20 citations
,
February 2017 in “International Journal of Dermatology” This review highlights recent findings on blood-derived autologous therapies for skin repair and wound healing but presents no new clinical results, emphasizing future challenges and prospects in regenerative dermatology.
19 citations
,
March 2018 in “Journal of Investigative Dermatology” This study indicates that transient Msx2 expression is critical for wound-induced hair follicle neogenesis, with distinct phases in the healing process essential for epidermal competence and hair regeneration.
19 citations
,
September 2015 in “Therapeutic Delivery” This review discusses the application of active transdermal technologies in cosmetic devices for skin restoration and enhancement, reporting no new clinical results.
19 citations
,
October 2008 in “Journal der Deutschen Dermatologischen Gesellschaft” This article reviews the cutaneous reactions and characteristic skin changes associated with chemotherapy, radiation therapy, and new targeted cancer treatments, reporting no new clinical results.
18 citations
,
September 2020 in “International Journal of Nanomedicine” This study found that both allogeneic and xenogeneic small extracellular vesicles from adipose tissue similarly enhanced soft tissue regeneration and wound healing in rat models, implying similar therapeutic effects across species.
17 citations
,
April 2021 in “Clinical Phytoscience” This review discusses the ethnobotanical uses and phytochemistry of Plumbago zeylanica L., highlighting its potential pharmacological benefits for conditions such as diabetes and cardiovascular disorders, but reports no new experimental findings.
17 citations
,
December 2010 in “Journal of Investigative Dermatology” This study found that higher levels of the protein Flii were associated with enhanced hair follicle regeneration and longer hair fibers in a mouse model.
16 citations
,
October 2008 in “Dermatologic Surgery” In this study, the novel powered FUE method was associated with faster harvesting time and lower graft transection rates compared to manual FUE in male patients with alopecia.
13 citations
,
November 2024 in “Frontiers in Microbiology” This review assessed the potential of mesenchymal stem cell therapy to enhance burn wound healing, highlighting its capabilities in promoting angiogenesis, reducing inflammation, and regenerating damaged tissues, while identifying preclinical and clinical challenges that need addressing to optimize treatment outcomes.
13 citations
,
January 2022 in “Stem cell reviews and reports” This study found that using cultured mesenchymal stem cells from mouse whisker hair follicle outer root sheath in wound healing reduced inflammation, accelerated closure, and resulted in less hypertrophic scarring in mice.
13 citations
,
September 2021 in “Communications Biology” This study introduces a five-modal microscopy technique that allows label-free, in vivo observation and quantitative analysis of various wound healing processes.
12 citations
,
February 2025 in “Scientific Reports” This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.
12 citations
,
September 2021 in “The International Journal of Developmental Biology” This review updates on the development of liposomal carriers for delivering growth factors to improve tissue regeneration and highlights recent efforts to enhance their stability and retention in tissues.
11 citations
,
February 2022 in “Scientific Reports” This study found that CD26+ fibroblasts are crucial for effective extracellular matrix production and achieving rapid epidermal and dermal homeostasis in human tissue-engineered skin substitutes transplanted onto rodents.
10 citations
,
September 2024 in “Journal of Nanobiotechnology” This study developed an antimicrobial microneedle patch for delivering apoptotic vesicles to treat infected wounds, which was found to effectively reduce bacterial growth and accelerate scarless healing, including the rapid formation of mature hair follicles in just 8 days, a previously unreported early outcome.
10 citations
,
August 2020 in “Indian Journal of Plastic Surgery/Indian journal of plastic surgery” This minireview discusses the mechanisms of facial aging, examines current literature, and proposes filler injection protocols, but it reports no new clinical results.
10 citations
,
October 2015 in “Medicina Clínica (english Edition)” This review discusses the therapeutic potential and safety of bioidentical recombinant human epidermal growth factor (rhEGF) for various skin and mucosa conditions and reports no new clinical results.