An Antimicrobial Microneedle Patch Promotes Functional Healing of Infected Wounds Through Controlled Release of Adipose Tissue-Derived Apoptotic Vesicles

    September 2024 in “ Journal of Nanobiotechnology ”
    Yue Ma, Jia Dong, Maojiao Li … Weidong Tian
    Studysummary This study developed an antimicrobial microneedle patch for delivering apoptotic vesicles to treat infected wounds, which was found to effectively reduce bacterial growth and accelerate scarless healing, including the rapid formation of mature hair follicles in just 8 days, a previously unreported early outcome.
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    Research cited in this study 5

    1. Human Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Encapsulated in Pluronic F127 Hydrogel Promote Wound Healing and Regeneration Stem Cell Research & Therapy · 2022
    2. Engineering Robust Ag-Decorated Polydopamine Nano-Photothermal Platforms to Combat Bacterial Infection and Promote Wound Healing Advanced Science · 2022
    3. Comparison of the Therapeutic Effect of Allogeneic and Xenogeneic Small Extracellular Vesicles in Soft Tissue Repair International Journal of Nanomedicine · 2020
    4. Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice Journal of Clinical Investigation · 2019
    5. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model Annals of Dermatology · 2016