Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing

February 2025 in “ Smart Medicine ”

Lu Fan, Li Wang, Xiaoju Wang, Minli Li, Hongcheng Gu, Hongbo Zhang

microneedle patch silk fibroin-methacryloyl gelatin methacryloyl silver nanoparticles vascular endothelial growth factor angiogenesis cell proliferation SilMA GelMA AgNPs VEGF

Studysummary In this study, a multifunctional microneedle patch made from silk fibroin-methacryloyl and gelatin methacryloyl was reported to significantly prevent bacterial infection and promote wound healing in vivo due to its antimicrobial silver nanoparticles and VEGF-loaded tips.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Drug Conjugates Crosslinked Bioresponsive Hydrogel for Combination Therapy of Diabetic Wound

October 2024 in “PubMed”

This study developed a bioresponsive hydrogel combining basic fibroblast growth factor and N-acetylcysteine, which significantly improved diabetic wound healing by enhancing re-epithelialization, collagen deposition, hair follicle regeneration, and neovascularization in response to oxidative stress.

Hydrogel Forming Microneedles Loaded With VEGF and Ritlecitinib/Polyhydroxyalkanoates Nanoparticles for Mini-Invasive Androgenetic Alopecia Treatment

research Hydrogel Forming Microneedles Loaded With VEGF and Ritlecitinib/Polyhydroxyalkanoates Nanoparticles for Mini-Invasive Androgenetic Alopecia Treatment

April 2024 in “Bioactive materials”

This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.

research A Stretchable Wireless Wearable Bioelectronic System for Multiplexed Monitoring and Combination Treatment of Infected Chronic Wounds

319 citations , March 2023 in “Science Advances”

This study demonstrated that a wearable bioelectronic patch with combined therapy significantly accelerated chronic wound healing in a rodent model by monitoring and treating wounds noninvasively.

research Injectable Polypeptide-Protein Hydrogels for Promoting Infected Wound Healing

262 citations , May 2020 in “Advanced Functional Materials”

This study demonstrated that a newly developed polypeptide-protein hydrogel with vascularization and antibacterial properties promoted tissue regeneration and hair follicle formation in infected wound healing.