Injectable Polypeptide-Protein Hydrogels for Promoting Infected Wound Healing

    May 2020 in “ Advanced Functional Materials ”
    Liang Cheng, Zhengwei Cai, Tingjun Ye, Xiaohua Yu, Zhijie Chen, Yufei Yan, Jin Qi, Lei Wang, Zhihong Liu, Wenguo Cui, Lianfu Deng, Liang Cheng, Zhengwei Cai, Tingjun Ye, Xiaohua Yu, Zhijie Chen, Yufei Yan, Jin Qi, Lei Wang, Zhihong Liu, Wenguo Cui, Lianfu Deng
    Studysummary This study demonstrated that a newly developed polypeptide-protein hydrogel with vascularization and antibacterial properties promoted tissue regeneration and hair follicle formation in infected wound healing. Our plain-language summary of this paper — not a Tressless recommendation.
    The study developed injectable polypeptide-protein hydrogels with vascularization and antibacterial properties for promoting infected wound healing. These hydrogels were constructed using bovine serum albumin and silver ions (Ag+) as crosslinkers, which provided a sterile environment and strong antibacterial capabilities. The hydrogels also incorporated the K2(SL)6K2 (KK) polypeptide, enhancing vascularization. In vivo results demonstrated significant collagen deposition and vascularization in the early stages of wound healing, leading to rapid tissue regeneration and the formation of new hair follicles. This multifunctional hydrogel showed promise for applications in biomedical fields, particularly in healing infected wounds.
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