TLDR The hydrogel with silver nanoparticles effectively heals MRSA-infected wounds.
The study presents an injectable hydrogel dressing, Ag@ADMH, designed to enhance healing of MRSA-infected wounds by combining a dermal matrix with silver nanoparticles. This hydrogel demonstrates sustained antibacterial efficacy and biocompatibility, promoting wound healing by reducing inflammation and encouraging tissue regeneration. In vitro and in vivo analyses show that Ag@ADMH decreases inflammatory markers and M1 macrophage polarization while increasing M2 macrophage presence, collagen synthesis, and vasculogenesis. These findings highlight Ag@ADMH as an effective strategy for treating infected wounds.
26 citations
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May 2023 in “Journal of Nanobiotechnology” The hydrogel speeds up healing of normal and MRSA-infected wounds.
13 citations
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February 2023 in “Pharmaceutics” The document reviewed the role of bioactive wound dressings in modulating macrophage function to enhance wound healing. It highlighted the importance of macrophages in normal wound healing and how their dysfunction can lead to chronic wounds. The review emphasized the strategy of promoting macrophage polarization towards the M2 phenotype to improve healing by reducing chronic inflammation, increasing anti-inflammatory cytokines, and stimulating angiogenesis and re-epithelialization. It discussed the use of extracellular matrix-based scaffolds and nanofibrous composites as promising materials for designing bioactive scaffolds to accelerate wound healing.
148 citations
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August 2022 in “Stem Cell Research & Therapy” Encapsulated stem cell exosomes in hydrogel improve wound healing.
61 citations
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September 2020 in “Bioactive Materials” A special dressing called FEA-PCEI can speed up wound healing, reduce scars, and help grow new hair follicles, but only at the right dosage.
