Designing Injectable Dermal Matrix Hydrogel Combined with Silver Nanoparticles for Methicillin-Resistant Staphylococcus Aureus Infected Wounds Healing
October 2024
in “
Nano Convergence
”
TLDR The hydrogel with silver nanoparticles effectively heals MRSA-infected wounds.
The study developed an injectable hydrogel, Ag@ADMH, combining silver nanoparticles and plant polyphenols to enhance healing of methicillin-resistant Staphylococcus aureus (MRSA) infected wounds. The hydrogel demonstrated significant antibacterial efficacy, with a 90.79% bactericidal rate against MRSA, and exhibited antioxidant and anti-inflammatory properties. It promoted M2 macrophage polarization, reduced inflammation, and enhanced tissue repair through collagen synthesis and angiogenesis. In vitro and in vivo experiments, including mouse and rat models, showed promising results in wound healing and immune response modulation. The hydrogel's design allows for gradual release of silver nanoparticles, minimizing cytotoxicity and enhancing stability, making it a potential candidate for clinical applications in treating chronic or infected wounds.
