Modulation of Macrophage Function by Bioactive Wound Dressings with an Emphasis on Extracellular Matrix-Based Scaffolds and Nanofibrous Composites

The document reviewed the role of bioactive wound dressings in modulating macrophage function to enhance wound healing. It highlighted the importance of macrophages in normal wound healing and how their dysfunction can lead to chronic wounds. The review emphasized the strategy of promoting macrophage polarization towards the M2 phenotype to improve healing by reducing chronic inflammation, increasing anti-inflammatory cytokines, and stimulating angiogenesis and re-epithelialization. It discussed the use of extracellular matrix-based scaffolds and nanofibrous composites as promising materials for designing bioactive scaffolds to accelerate wound healing.