Multifunctional Antibacterial Bioactive Nanoglass Hydrogel for Normal and MRSA Infected Wound Repair

The study explores the development and effectiveness of a multifunctional antibacterial bioactive nanoglass hydrogel (FABA) for wound repair, particularly targeting Methicillin-resistant Staphylococcus aureus (MRSA) infections. The FABA hydrogel, composed of F127-CHO, BGNCu, and alendronate sodium, exhibits strong antibacterial and anti-inflammatory properties, promoting faster wound healing in both normal and MRSA-infected wounds. It significantly accelerates wound closure, achieving 75% closure for normal wounds and 70% for MRSA-infected wounds by day 3, which is nearly three times faster than untreated wounds. The study involved 90 mice and demonstrated that FABA hydrogel outperformed other treatments, highlighting its potential as an effective wound dressing. However, further research is needed to fully understand the molecular mechanisms behind its effects.