Microneedle Array Patch Made of Kangfuxin/Chitosan/Fucoidan Complex Enables Full-Thickness Wound Healing

January 2022 in “ Frontiers in Chemistry ”

Xixi Yu, Caixia Wang, Yuanfei Wang, Longhao Li, Xiang Gao, Tingting Zhu, Pu-Gen An, Zhaojian Meng, Wanchun Wang, Tong Wu, Yuanping Hao

microneedle array patch kangfuxin chitosan fucoidan stratum corneum transdermal drug delivery epithelial thickness collagen deposition marine polysaccharides traditional Chinese medicine

TLDR The patch speeds up deep wound healing.

The study developed a microneedle array patch made from a blend of kangfuxin, chitosan, and fucoidan (KCFMN) to enhance full-thickness wound healing. The patch was designed to penetrate the stratum corneum, facilitating effective transdermal drug delivery. The KCFMN patch demonstrated significant antibacterial properties and cytocompatibility, and it notably accelerated wound healing in rats by increasing epithelial thickness and collagen deposition. This innovative patch showed promise as a dressing for full-thickness wound healing, leveraging the beneficial properties of marine polysaccharides and traditional Chinese medicine.

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