A Cu@ZIF-8 Encapsulated Antibacterial and Angiogenic Microneedle Array for Promoting Wound Healing

    January 2023 in “ Nanoscale Advances ”
    Jieyu Xiang, Yufan Zhu, Yuanlong Xie, Hang Chen, Ling Zhou, Danyang Chen, Jia Guo, Min Wang, Lin Cai, Liang Guo
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    TLDR The microneedle arrays effectively promote wound healing and have potential for clinical use.
    The study developed Cu@ZIF-8 encapsulated microneedle arrays (MNs) to enhance wound healing, demonstrating strong antibacterial and pro-angiogenic properties. These MNs, made from PEGDA and CMCS hydrogels, showed good biocompatibility and mechanical strength, effectively promoting wound healing in a rat model with 12 male Sprague-Dawley rats. The Cu@ZIF-8 nanoparticles generated reactive oxygen species, enhancing antibacterial efficacy against bacteria like E. coli and S. aureus, while the release of copper ions promoted angiogenesis. In vitro and in vivo tests revealed accelerated wound healing, improved re-epithelialization, and collagen deposition. The study concluded that these MNs offer a promising minimally invasive approach for drug delivery and wound repair, with potential clinical applications.
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