Multifunctional NIR-Triggered Nanozyme-Based Microneedles for Synergistic Eradication of MRSA and Enhanced Wound Healing

The study introduces MN@CTB microneedle patches as a novel treatment for MRSA-infected wounds, utilizing a combination of nitric oxide-mediated photothermal therapy and gas therapy to eradicate bacteria and enhance wound healing. These patches exhibit strong antibacterial, antioxidant, and anti-inflammatory properties, effectively reducing oxidative stress and promoting angiogenesis and tissue regeneration. In vivo tests on mice demonstrated significant wound size reduction and improved healing outcomes, including collagen deposition and hair follicle regeneration. The patches work by inhibiting the NF-κB signaling pathway and activating VEGF and TGF-β pathways, leading to decreased inflammation and enhanced healing. This multifunctional approach offers a promising, low-toxicity therapeutic strategy for managing bacterial-associated wounds.