Three-In-One Multifunctional Metal-Organic Gel-Encapsulated Microneedles for Programmed Treatment of Infected Wounds

The study introduces a multifunctional metal-organic gel-encapsulated microneedle (Cu-MOG MN) designed for the treatment of infected wounds caused by multidrug-resistant bacteria. This system integrates antibacterial, anti-inflammatory, and pro-angiogenic properties to address the challenges of biofilm formation, persistent inflammation, and impaired angiogenesis in refractory wounds. Cu-MOG is created through the coordination of phytic acid and copper, exhibiting pH-responsive multienzyme activities. Initially, it generates reactive oxygen species to eradicate bacteria and disrupt biofilms. As inflammation subsides, it shifts to scavenging excess ROS, reducing oxidative stress, and promoting macrophage polarization to the M2 phenotype, enhancing collagen deposition, angiogenesis, and cell migration. This comprehensive approach offers a promising solution for the precise and adaptive treatment of challenging wounds.