Three-In-One Multifunctional Metal-Organic Gel-Encapsulated Microneedles for Programmed Treatment of Infected Wounds
February 2026
in “
Advanced Healthcare Materials
”
TLDR The microneedles effectively treat infected wounds by killing bacteria, reducing inflammation, and promoting healing.
The study introduces a multifunctional metal–organic gel-encapsulated microneedle (Cu-MOG MN) designed for the treatment of infected wounds caused by multidrug-resistant bacteria. This innovative system integrates antibacterial, anti-inflammatory, and pro-angiogenic properties. The Cu-MOG is formed through the coordination of phytic acid and copper, exhibiting pH-responsive multienzyme activities. Initially, it generates reactive oxygen species to eradicate bacteria and disrupt biofilms. As the wound environment stabilizes, it shifts to scavenging excess ROS, reducing oxidative stress, and promoting macrophage polarization to the M2 phenotype. This enhances collagen deposition, angiogenesis, and cell migration, accelerating wound healing. The Cu-MOG MN system offers a comprehensive therapeutic approach with deep tissue penetration and adaptive treatment capabilities for refractory wounds.
