Exploring the Therapeutic Potential of Different Sources of Mesenchymal Stem Cells: A Novel Approach to Combat Burn Wound Infections

    November 2024 in “ Frontiers in Microbiology ”
    Shahrzad Aliniay-Sharafshadehi, Mohammad Hasan Yousefi, Mohammad Ghodratie, Mojtaba Kashfi, Hamed Afkhami, Seyed Mehdi Ghoreyshiamiri
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    Studysummary This review assessed the potential of mesenchymal stem cell therapy to enhance burn wound healing, highlighting its capabilities in promoting angiogenesis, reducing inflammation, and regenerating damaged tissues, while identifying preclinical and clinical challenges that need addressing to optimize treatment outcomes. Our plain-language summary of this paper — not a Tressless recommendation.
    Burn injuries pose significant global health challenges due to their potential to cause severe inflammatory responses, organ dysfunction, and infections that can lead to sepsis. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach for enhancing burn wound healing. Since 2000, MSCs have been increasingly used in regenerative medicine due to their ability to promote angiogenesis, exhibit anti-inflammatory effects, and regenerate damaged tissue. These cells can be sourced from bone marrow, fat, umbilical cord, and amniotic membrane. The review highlights the need to address preclinical and clinical challenges to optimize MSC therapy, thereby advancing its application in treating burn wounds and reducing scarring and associated functional and cosmetic issues.
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