Mesenchymal Stem Cells Paracrine Proteins From Three-Dimensional Dynamic Culture System Promoted Wound Healing in Third-Degree Burn Models
July 2023
in “
Bioengineering & translational medicine
”
mesenchymal stem cell paracrine proteins 3D dynamic culture system PEG thermogel dermal fibroblasts keratinocytes re-epithelialization skin appendage recovery angiogenesis CD26+/Sca-1+ cells Dlk-1+/Sca-1+ cells MSC-PP 3D culture PEG gel fibroblasts skin cells new skin formation blood vessel formation
Studysummary This study explored a cell-free therapy with mesenchymal stem cell paracrine proteins and PEG hydrogels for deep burn treatment and found that the combination significantly enhanced wound healing, reduced scar formation, and promoted skin appendage regeneration in a rabbit model.
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