Mesenchymal Stem Cells Paracrine Proteins From Three-Dimensional Dynamic Culture System Promoted Wound Healing in Third-Degree Burn Models

July 2023 in “ Bioengineering & translational medicine ”

Yingwei Wang, WU Jia-xin, Jiamin Chen, Cheng-You Lu, Jinchao Liang, Yingyi Shan, Jie Liu, Qi Li, Miao Liu, Mu He, Xiaoying Wang, J Zhang, Zheng Wu

mesenchymal stem cell paracrine proteins 3D dynamic culture system PEG thermogel dermal fibroblasts keratinocytes re-epithelialization skin appendage recovery angiogenesis CD26+/Sca-1+ cells Dlk-1+/Sca-1+ cells MSC-PP 3D culture PEG gel fibroblasts skin cells new skin formation blood vessel formation

TLDR Mesenchymal stem cell proteins in a special gel improved healing of severe burns.

The study demonstrated that mesenchymal stem cell paracrine proteins (MSC-PP) derived from a 3D dynamic culture system, combined with PEG thermogel, significantly improved wound healing in third-degree burn models. The MSC-PP treatment enhanced the migration and proliferation of dermal fibroblasts and keratinocytes, reduced inflammation, and promoted re-epithelialization, skin appendage recovery, and angiogenesis. The PEG thermogel provided a stable release of MSC-PP and exhibited no cytotoxicity, making it an effective carrier for MSC-PP delivery. The MSC-PP + PEG group showed the most effective wound contraction, minimal scarring, and the highest presence of CD26+/Sca-1+ and Dlk-1+/Sca-1+ cells, which are crucial for inhibiting scar formation.

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