Safety and Biocompatibility of Mupirocin Nanoparticle-Loaded Hydrogel on Burn Wounds in a Rat Model

    October 2021 in “ Biological and Pharmaceutical Bulletin ”
    Sukanjana Kamlungmak, Titpawan Nakpheng, Sunisa Kaewpaiboon, Muhammad Ali Khumaini Mudhar Bintang, Supattra Prom-in, Charisopon Chunhachaichana, Tan Suwandecha, Teerapol Srichana
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    Studysummary This study found that mupirocin nanoparticle-loaded hydrogel was safe and more effective for healing burn wounds in rats compared to mupirocin ointment, showing promise for future clinical trials. Our plain-language summary of this paper — not a Tressless recommendation.
    The study developed a mupirocin nanoparticle-loaded hydrogel (MLH) and evaluated its safety and biocompatibility for wound healing in rat models. MLH showed no toxicity to human epidermal keratinocytes and fibroblast cells and effectively inhibited inflammatory responses in macrophage-like cells. In rat burn wounds, MLH and blank hydrogel demonstrated superior healing compared to mupirocin ointment, evidenced by better wound contraction, reduced secretion, new blood vessel formation, and promotion of hair follicle cells. MLH also resulted in less necrosis, lower inflammation, and reduced macrophage presence. The study concluded that MLH was safe and effective for burn wound healing, suggesting its potential for clinical trials.
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