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research 22 Biological functions of exosome-like nanoparticles isolated from rose (rosa damascena) stem cell culture (RSCE)

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, exosome-like nanoparticles derived from rose stem cell culture were found to enhance skin quality by increasing collagen production, reducing melanin and inflammation, and promoting cell migration in vitro, suggesting potential aesthetic applications.

research 176 Myeloid cell-specific deletion of mTOR suppresses psoriasis-like skin inflammation in C57BL/6 mice

April 2023 in “Journal of Investigative Dermatology”

This study reports that CD200R expression is significantly reduced in a mouse model of scarring alopecia, suggesting a potential role for this pathway in immune regulation and hair follicle protection.

research CD169+ Skin Macrophages Function as a Specialized Subpopulation in Promoting Psoriasis-like Skin Disease in Mice

2 citations , May 2024 in “International Journal of Molecular Sciences”

This study found that in a mouse model of psoriasis, depleting CD169⁺ macrophages led to milder symptoms and decreased inflammation, suggesting these macrophages play a crucial role in psoriasis development.

research Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model

3 citations , September 2024 in “Journal of Microbiology and Biotechnology”

This study found that human placenta hydrolysate effectively inhibited atopic dermatitis development in stimulated human cells and a mouse model, suggesting its potential as a therapeutic agent for related skin diseases.

research Mechanical stretch induces hair regeneration through the alternative activation of macrophages

163 citations , April 2019 in “Nature Communications”

This study found that mechanical skin stretching can stimulate hair stem cell proliferation and hair regeneration by activating a complex pathway involving WNT, BMP-2, and M2 macrophages.

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community You will lose hair if your prostaglandins aren't in balance

56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 1 month ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

community 2/3 non response rate to pp405?

10 months ago

PP405 showed 31% regrowth in a short trial, but its effectiveness is debated compared to Minoxidil and Finasteride. Some argue AGA isn't scarring, while others believe it leads to fibrosis, affecting treatment outcomes.

community The Worst Hair Loss Condition You (MAY) have: LPP

48 upvotes 2 years ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community A Study I came along by mistake researching (Dutasteride +Pumpkin seed oil ) for every other day use.

16 upvotes 3 months ago

Alternating Dutasteride with pumpkin seed oil may protect the spleen from damage caused by Dutasteride. Pumpkin seed oil's antioxidants help counteract oxidative stress and immune suppression.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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