CD169+ Skin Macrophages Function as a Specialized Subpopulation in Promoting Psoriasis-Like Skin Disease in Mice
May 2024
in “
International Journal of Molecular Sciences
”
Studysummary This study found that in a mouse model of psoriasis, depleting CD169<sup>+</sup> macrophages led to milder symptoms and decreased inflammation, suggesting these macrophages play a crucial role in psoriasis development.
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This study explores the role of CD169+ skin macrophages in promoting psoriasis-like skin disease in mice. It was found that these macrophages are a specialized subpopulation that increases in number and moves closer to the epidermis during psoriasis progression. Depleting CD169+ macrophages in mice alleviated psoriasis symptoms, reduced proinflammatory cytokine levels, and decreased Th17 cells in skin lesions. Transcriptomic analysis revealed a unique gene expression profile in CD169+ macrophages, highlighting their enhanced ability to produce cytokines and promote Th17 cell differentiation. These findings suggest that targeting CD169+ macrophages could be a potential therapeutic strategy for psoriasis.
