CD271 Orchestrates Skin Structure, Differentiation, And Inflammation Via PI3K/Akt And PKCα/ERK Pathways

    October 2025 in “ Cell Death and Disease ”
    Marika Quadri, Luca Reggiani Bonetti, Cristina Pellegrini, Mirco Mastrangelo, Andrea Caporali, Cristina Vaschieri, Roberta Lotti, Maria Concetta Fargnoli, Carlo Pincelli, Alessandra Marconi, Elisabetta Palazzo
    TLDR CD271 is crucial for maintaining healthy skin and preventing inflammation.
    The study investigates the role of the neurotrophin receptor CD271 in skin conditions like psoriasis and squamous cancer, focusing on its impact on keratinocytes. Researchers developed two mouse models, CD271cKO and CD271ciKO, to study CD271's absence in keratinocytes. Findings revealed that CD271 deletion leads to significant skin changes, such as epidermal hyperproliferation, delayed differentiation, and an "activated" keratinocyte signature, primarily through PI3K/Akt and mitogenic pathways. The knockout models showed increased expression of markers like Ki67 and inflammatory cytokines, resembling dysplastic skin conditions with immune cell recruitment. The study concludes that CD271 is vital for skin homeostasis and these models are valuable for understanding skin pathophysiology and developing therapies.
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