Myeloid Cell-Specific Deletion of mTOR Suppresses Psoriasis-Like Skin Inflammation in C57BL/6 Mice

    April 2023 in “ Journal of Investigative Dermatology ”
    S.T. Boateng, T. Roy, S. Banang-Mbeumi, R.N. Chamcheu, S. Patial, K.G. Kousoulas, J. Chamcheu
    TLDR Targeting mTOR in myeloid cells may help reduce psoriasis symptoms.
    This study explores the role of mTOR signaling in myeloid lineage cells in the development of psoriasis, an autoimmune skin disorder. Using a genetic mouse model with myeloid-specific deletion of mTOR, researchers found that these mice exhibited significantly less severe psoriasis-like skin inflammation compared to control mice. The mTOR-deficient mice showed reduced psoriasiform skin lesions, lower PASI scores, and decreased levels of immune cell infiltration, including helper T-lymphocytes, dendritic cells, and macrophages. These findings suggest that targeting mTOR in myeloid cells could be a potential therapeutic strategy for alleviating psoriasis.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 7 results

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  143 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community How uninformed the general public is about hair loss

      in Chat  318 upvotes 10 months ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

      community One full year progress on fin + min

      in Progress Pictures  517 upvotes 11 months ago
      A user shared their one-year progress using finasteride and minoxidil for hair loss, showing significant improvement. They also mentioned using the medication inconsistently and considering changes to their shampoo routine.

      community 22 yr asian male 2 year fin results

      in Progress Pictures  135 upvotes 1 year ago
      The user "Top_Replacement_7777" shared their positive results with finasteride for hair loss. They asked about maintaining their hair with finasteride and the impact of vaping on hair growth. Another user reassured them that vaping wouldn't affect their progress.

    Similar Research

    5 / 638 results