Myeloid Cell-Specific Deletion of mTOR Suppresses Psoriasis-Like Skin Inflammation in C57BL/6 Mice
April 2023
in “
Journal of Investigative Dermatology
”
Studysummary This study reports that CD200R expression is significantly reduced in a mouse model of scarring alopecia, suggesting a potential role for this pathway in immune regulation and hair follicle protection.
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This study explores the role of mTOR signaling in myeloid lineage cells in the development of psoriasis, an autoimmune skin disorder. Using a genetic mouse model with myeloid-specific deletion of mTOR, researchers found that these mice exhibited significantly less severe psoriasis-like skin inflammation compared to control mice. The mTOR-deficient mice showed reduced psoriasiform skin lesions, lower PASI scores, and decreased levels of immune cell infiltration, including helper T-lymphocytes, dendritic cells, and macrophages. These findings suggest that targeting mTOR in myeloid cells could be a potential therapeutic strategy for alleviating psoriasis.
