Targeting mTORC1 May Provide Selectivity for Inhibiting Proliferation of Hair Follicle Stem/Progenitor Cells During Tumor Promotion
April 2012
in “
Cancer research
”
mTORC1 hair follicle stem/progenitor cells TPA PKC EGFR Akt rapamycin epidermal hyperplasia label-retaining cells bulge region keratinocyte populations bulge-region KSCs mammalian target of rapamycin complex 1 hair follicle stem cells 12-O-tetradecanoylphorbol-13-acetate protein kinase C epidermal growth factor receptor protein kinase B sirolimus skin thickening LRCs hair follicle bulge skin cells bulge-region keratinocyte stem cells
Studysummary In this study, the authors found that targeting mTORC1 with rapamycin inhibited TPA-induced skin tumor promotion by affecting keratinocyte proliferation, including critical stem cell populations in the mouse epidermis.
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