Biological Functions of Exosome-Like Nanoparticles Isolated from Rose (Rosa Damascena) Stem Cell Culture

    November 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    B.S. Cho
    TLDR Rose stem cell nanoparticles improve skin quality by boosting collagen, aiding cell movement, reducing melanin, and lowering inflammation.
    Researchers isolated exosome-like nanoparticles (RSCE) from rose stem cell culture media and found that these nanoparticles have significant biological effects on skin. RSCEs, sized 30-200 nanometers, contain over 1,000 types of miRNA, mostly related to housekeeping functions. They were shown to increase collagen production in fibroblasts by 40-120%, enhance cellular migration by over 20%, reduce melanin production by 60-80%, and decrease IL-6 production in macrophages by 50-60%, indicating anti-inflammatory properties. These findings suggest that RSCEs have potential applications in improving skin quality and aesthetics.
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