Biological Functions of Exosome-Like Nanoparticles Isolated from Rose (Rosa Damascena) Stem Cell Culture

November 2023 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

B.S. Cho

exosome-like nanoparticles rose stem cell culture RSCE collagen production fibroblasts cellular migration melanin production IL-6 macrophages anti-inflammatory properties exosomes rose stem cells collagen skin cells inflammation

TLDR Rose stem cell nanoparticles improve skin quality by boosting collagen, aiding cell movement, reducing melanin, and lowering inflammation.

Researchers isolated exosome-like nanoparticles (RSCE) from rose stem cell culture media and found that these nanoparticles have significant biological effects on skin. RSCEs, sized 30-200 nanometers, contain over 1,000 types of miRNA, mostly related to housekeeping functions. They were shown to increase collagen production in fibroblasts by 40-120%, enhance cellular migration by over 20%, reduce melanin production by 60-80%, and decrease IL-6 production in macrophages by 50-60%, indicating anti-inflammatory properties. These findings suggest that RSCEs have potential applications in improving skin quality and aesthetics.

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Biological Functions of Exosome-Like Nanoparticles Isolated from Rose (Rosa Damascena) Stem Cell Culture

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