Human Placenta Extract Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis-Like Mouse Model
September 2024
in “
Journal of Microbiology and Biotechnology
”
human placenta extract HPH atopic dermatitis AD TNF-α IFN-γ HaCaT cells DNCB reactive oxygen species ROS Nrf2 filaggrin IL-6 TARC nuclear factor kappa B mast cell macrophage epidermal thickness IL-4 IL-5 IL-13 RANTES IgE placenta extract tumor necrosis factor alpha interferon gamma keratinocytes interleukin-6 thymus and activation-regulated chemokine interleukin-4 interleukin-5 interleukin-13 regulated on activation, normal T cell expressed and secreted immunoglobulin E
Studysummary This study found that human placenta hydrolysate effectively inhibited atopic dermatitis development in stimulated human cells and a mouse model, suggesting its potential as a therapeutic agent for related skin diseases.
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