50 citations
,
December 2020 in “Bioactive Materials” This study suggests that a sandwich-structured wound dressing with bioceramic and polylactic acid layers may improve burn wound healing by absorbing exudates and promoting hair follicle regeneration.
13 citations
,
September 2022 in “Materials & design” This study found that astaxanthin-loaded mucoadhesive patches effectively promoted recovery of oral premalignant lesions in vivo without the side effects seen with clinical tretinoin cream.
8 citations
,
May 2021 in “Applied Materials Today” This study found that Cur-Fe-mesoporous silica nanoparticles synergistically inhibited scar formation and promoted hair follicle regeneration in skin burn wound healing by releasing bioactive components like SiO32−, Fe3+, and Fe-Cur chelates.
4 citations
,
May 2012 in “Tissue Engineering and Regenerative Medicine” This study demonstrated the potential of epithelial cell scaffolds fabricated with various materials for effective hair regeneration, highlighting their promising application in tissue engineering for alopecia treatment.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study introduced hydrogel microneedles loaded with palladium nanoparticles, which utilize the inherent cytotoxicity of polyethyleneimine to enhance the effectiveness of doxorubicin in treating melanoma, achieving a tumor inhibition rate of up to 98% in a murine model.
213 citations
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September 2020 in “Journal of Functional Biomaterials” This review discusses bio-based polymers, highlighting their potential in wound healing applications, but reports no new clinical results.
169 citations
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October 2020 in “Pharmaceutics” This review discusses recent advancements in formulating electrospun nanofibers as wound dressings, emphasizing their advantages in incorporating bioagents for improved healing, but reports no new clinical results.
67 citations
,
February 2022 in “International Journal of Molecular Sciences” This study developed a nanofiber wound dressing combining ciprofloxacin and tetracycline hydrochloride, which demonstrated strong antibacterial activity against E. coli and S. aureus and showed good biocompatibility with human skin fibroblast cells, indicating significant potential for wound healing applications.
216 citations
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February 2022 in “Nanomaterials” This review discusses the potential of electrospun gelatin-based nanofiber dressings for wound healing and skin regeneration, detailing their properties, enhanced functionalities through crosslinking and bioactive components, and their application in treating challenging wound types like burns and diabetic wounds.
25 citations
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July 2019 in “Journal of drug delivery science and technology” This study developed lipid-core nanocapsules for encapsulating menthol, improving its solubility and thermal stability, and demonstrated their safety and rapid skin absorption in ex vivo tests, highlighting potential applications for cosmeceuticals.
16 citations
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September 2021 in “Frontiers in Bioengineering and Biotechnology” In this study, chitosan-modified fucoidan/polyethylene oxide nanofibers were developed, showing promise as bio-scaffolds for tissue-engineered blood vessels by enhancing endothelial cell adhesion and inhibiting monocyte attachment.
9 citations
,
March 2023 in “Biomimetics” This review discusses current strategies and materials in tissue engineering for skin regeneration, emphasizing design approaches and suggesting directions for future research; it reports no new clinical findings.
16 citations
,
March 2024 in “International Journal of Molecular Sciences” This review highlights how natural compounds can enhance wound healing by influencing fibroblast behavior and discusses innovative biomimetic engineering and delivery methods. This source emphasizes combining traditional and modern approaches for effective and scar-free healing, while noting challenges in clinical translation.
12 citations
,
September 2020 in “Nanomaterials” This study found that centrifugally spun scaffolds with higher concentrations of platelet-derived bioactive molecules enhanced melanocyte metabolic activity and proliferation, suggesting potential for improving vitiligo treatment.
110 citations
,
August 2011 in “Journal of Visualized Experiments” This research highlights the use of 3D human skin model reconstructs as a promising method to study human skin biology, showing that these models replicate natural melanocyte and melanoma behaviors accurately.
78 citations
,
February 2024 in “ACS Omega” This study developed a bilayer material combining poly(vinyl alcohol) and bacterial cellulose with a gelatin-poly(vinyl alcohol) hydrogel, showing strong potential as a wound dressing due to its good antibacterial properties, cell viability, and sustained drug release.
54 citations
,
May 2021 in “Chemical Engineering Journal” This study found that a novel hybrid bilayer scaffold system enhanced wound healing in an in-vivo model by promoting cell viability, migration, and preventing infection, showing potential as an advanced dressing for cutaneous wounds.
30 citations
,
February 2022 in “Pharmaceutics” This review explores recent advancements in skin tissue engineering using 3D bioprinting, discussing current methods, bioink formulations, and outlining both achievements and limitations without presenting new clinical results.
3 citations
,
January 2025 in “International Journal of Molecular Sciences” In this study, researchers investigated EGCG's spectroscopic properties and its interaction with DPPG lipid, finding that both experimental and theoretical approaches agree on the electronic transitions and reveal an increased absorbance due to molecular interactions.
1 citations
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June 2025 in “Journal of Materials Science Materials in Medicine” This study reports that multifunctional electrospun scaffolds containing silver vanadate, hydroxyapatite, and graphene oxide significantly improved wound healing in a rat model, promoting rapid re-epithelialization, enhanced mechanical properties, and strong antibacterial activity, making them promising candidates for advanced wound care applications.
16 citations
,
December 2018 in “ACS Biomaterials Science & Engineering” This research found that a biodegradable fibrous membrane incorporating fibroblast-derived ECM accelerated wound healing and improved neovascularization in a mouse model.
45 citations
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March 2020 in “ACS Applied Materials & Interfaces” In this study, researchers created a novel fibrous membrane inspired by ancient Chinese medicine that effectively promotes hair follicle regeneration and wound healing in deep burn injuries by releasing quercetin, copper, and silicon ions.
182 citations
,
June 2017 in “Biomaterials” This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.
38 citations
,
November 2024 in “Scientific Reports” This study developed electrospun nanofibers containing mupirocin for wound treatment, reporting enhanced antibacterial activity, high water absorption, and accelerated wound healing in a rat model, suggesting potential use for severe skin injuries at risk of infection.
2 citations
,
December 2022 in “PÄDI Boletín Científico de Ciencias Básicas e Ingenierías del ICBI” This review provides an overview of composite scaffold materials for skin that mimic natural dermal tissue, and highlights their potential in treating chronic wounds like diabetic foot by promoting cellular growth.
1 citations
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November 2024 in “Romanian Journal of Morphology and Embryology” This overview examines the biology, origin, structure, and function of various cells and structures, such as the blood-retinal barrier and Merkel cells, and discusses their roles in disease pathogenesis, along with recent findings related to the lymph nodes' paracortex.
November 2025 in “Nanoscale Advances” This review highlights the potential of inorganic nanoparticle-based scaffolds as innovative tools for advanced wound care, emphasizing their ability to provide antimicrobial action and regenerative support, while also discussing fabrication strategies and challenges in optimizing their clinical application.
8 citations
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May 2024 in “ACS Applied Materials & Interfaces” This study found that incorporating PCL-based nanoscaffolds into liver spheroids enhances their viability and liver-specific biofunctionality, suggesting these scaffolds improve the model's potential for preclinical drug screening by increasing sensitivity to acetaminophen toxicity compared to traditional methods.
April 2024 in “Materials today bio” In this study, the researchers developed a novel wound dressing incorporating copper-doped calcium silicate and curcumin, which significantly promoted nerve and blood vessel regeneration in deep burn wounds, emphasizing the crucial role of bioactive chelation in neuralized skin repair.
28 citations
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September 2023 in “International Journal of Biological Macromolecules” Animal experiments in this study demonstrated that a new sandwich-like fiber/sponge dressing design, which enhances wound healing through improved moisture management and faster exudate evaporation, resulted in more significant wound size reduction compared to commercial and control dressings.