Fabrication of Astaxanthin-Loaded Electrospun Nanofiber-Based Mucoadhesive Patches With Water-Insoluble Backing for the Treatment of Oral Premalignant Lesions

    September 2022 in “ Materials & design ”
    Hui Zhang, Yanjing Ji, Changqing Yuan, Peng Sun, Quanchen Xu, Defu Lin, Zeyu Han, Xinkai Xu, Qihui Zhou, Jing Deng
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    Studysummary This study found that astaxanthin-loaded mucoadhesive patches effectively promoted recovery of oral premalignant lesions in vivo without the side effects seen with clinical tretinoin cream. Our plain-language summary of this paper — not a Tressless recommendation.
    The study developed astaxanthin-loaded polycaprolactone/gelatin nanofiber-based mucoadhesive patches with a water-insoluble backing for treating oral premalignant lesions. These patches adhered well to the oral mucosa, ensuring a sustained release of astaxanthin, which effectively permeated the buccal mucosa. In vivo experiments on rats showed significant therapeutic efficacy by reducing Ki67 and COX-2 expression, comparable to clinical tretinoin cream, but without side effects like hair loss or oral ulcers. The results suggest that these patches hold great potential for OPL treatment.
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