Fabrication of Astaxanthin-Loaded Electrospun Nanofiber-Based Mucoadhesive Patches With Water-Insoluble Backing for the Treatment of Oral Premalignant Lesions

    November 2022 in “ Materials & design ”
    Hui Zhang, Yanjing Ji, Changqing Yuan, Peng Sun, Quanchen Xu, Defu Lin, Zeyu Han, Xinkai Xu, Qihui Zhou, Jing Deng
    TLDR The new patch for treating mouth sores releases medicine slowly, sticks well, and helps healing without the side effects of current creams.
    The study developed astaxanthin-loaded polycaprolactone/gelatin nanofiber-based mucoadhesive patches with a water-insoluble backing for treating oral premalignant lesions. These patches adhered well to the oral mucosa, ensuring a sustained release of astaxanthin, which effectively permeated the buccal mucosa. In vivo experiments on rats showed significant therapeutic efficacy by reducing Ki67 and COX-2 expression, comparable to clinical tretinoin cream, but without side effects like hair loss or oral ulcers. The results suggest that these patches hold great potential for OPL treatment.
    Discuss this study in the Community →