Fabrication of Astaxanthin-Loaded Electrospun Nanofiber-Based Mucoadhesive Patches With Water-Insoluble Backing for the Treatment of Oral Premalignant Lesions

    September 2022 in “ Materials & design ”
    Hui Zhang, Yanjing Ji, Changqing Yuan, Peng Sun, Quanchen Xu, Defu Lin, Zeyu Han, Xinkai Xu, Qihui Zhou, Jing Deng
    Image of study
    TLDR The new patch for treating mouth sores releases medicine slowly, sticks well, and helps healing without the side effects of current creams.
    The study developed astaxanthin-loaded polycaprolactone/gelatin nanofiber-based mucoadhesive patches with a water-insoluble backing for treating oral premalignant lesions. These patches adhered well to the oral mucosa, ensuring a sustained release of astaxanthin, which effectively permeated the buccal mucosa. In vivo experiments on rats showed significant therapeutic efficacy by reducing Ki67 and COX-2 expression, comparable to clinical tretinoin cream, but without side effects like hair loss or oral ulcers. The results suggest that these patches hold great potential for OPL treatment.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 15 results

      community New Study - Flavonoids More Effective Than Finasteride?

      in Research/Science  148 upvotes 1 year ago
      A recent publication suggests that the flavonoids eriocitrin and silymarin may be more effective than finasteride in binding to the enzyme responsible for hair loss. People in the conversation are skeptical about the effectiveness and safety of these flavonoids until tested on humans, and some discuss their personal experiences with other treatments.

      community Hopefully a logical question regarding dermarolling.

      in Microneedling 4 years ago
      A user discusses using dermastamping for hair loss and questions the timing of applying a mixture of peppermint oil, spearmint oil, rosemary oil, and castor oil due to their anti-inflammatory effects. They wonder if waiting 10 hours after stamping would be more effective.

      community Natural Remedies: Polyphenols and Hair Loss

       19 upvotes 5 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community Ultimate Stack without nuking your gender (you'll go broke)

      in Treatment  79 upvotes 3 weeks ago
      A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

      community What is everyone's stack and why?

      in Treatment  21 upvotes 2 months ago
      People are using various treatments for hair loss, including dutasteride, finasteride, minoxidil (both oral and topical), RU58841, and ketoconazole shampoo. Some also use additional methods like microneedling, vitamins, and oils, with mixed results and personal preferences influencing their choices.

    Similar Research

    5 / 52 results