Synergistic Effect of Co-Delivering Ciprofloxacin and Tetracycline Hydrochloride for Enhanced Wound Healing Using Coaxial PCL/Gelatin Nanofiber Membrane

    February 2022 in “ International Journal of Molecular Sciences ”
    Mengxia Lin, Yuan Liu, Junwei Gao, Donghui Wang, Dan Xia, Chunyong Liang, Ning Li, Ruodan Xu
    TLDR The nanofiber membranes effectively promote wound healing and have strong antibacterial properties.
    The study developed coaxial PCL/gelatin nanofiber membranes for enhanced wound healing by co-delivering ciprofloxacin (CIP) and tetracycline hydrochloride (TH). These nanofibers demonstrated strong antibacterial activity against E. coli and S. aureus, with TH providing rapid release and CIP offering sustained release, promoting antibacterial synergy and reducing drug resistance. The core-shell structure improved mechanical properties, hydrophilicity, and water absorption, making them suitable for wound dressings. The nanofibers showed high biocompatibility with human skin fibroblast cells and maintained antibacterial efficiency over 5 days, indicating their potential as effective wound dressing materials.
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