A Simple Drug Delivery System for Platelet-Derived Bioactive Molecules to Improve Melanocyte Stimulation in Vitiligo Treatment

    September 2020 in “ Nanomaterials ”
    Karolína Vocetková, Věra Sovková, Matěj Buzgo, Věra Lukášová, Radek Divín, Michala Rampichová, Pavel Blažek, Tomáš Zikmund, Jozef Kaiser, Zdeněk Karpíšek, Evžen Amler, Eva Filová
    TLDR The new drug delivery system improves vitiligo treatment by enhancing melanocyte activity and viability.
    The study focused on developing a simple drug delivery system using poly-ε-caprolactone (PCL) fibrous scaffolds to enhance the effects of platelet-derived bioactive molecules for vitiligo treatment. It was found that centrifugally spun scaffolds released nearly twice the amount of bioactive molecules compared to electrospun scaffolds, with a sustained release over 14 days. The study demonstrated a strong concentration-dependent response, where higher concentrations of bioactive molecules improved melanocyte metabolic activity and proliferation. This system was shown to improve melanocyte viability and is suitable for prolonged topical administration of platelet-rich plasma (PRP).
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