Synergistic Delivery of Ginseng Exosomes and Biomimetic Melanosomes via Temporally Controlled Hydrogel Microneedles Restrain the Pathologic Triad of Vitiligo
March 2026
in “
Journal of Nanobiotechnology
”
ginseng exosomes biomimetic melanosomes hydrogel microneedles vitiligo methacrylated hyaluronic acid polydopamine nanoparticles glyceryl monostearate micelles oxidative stress inflammation melanocyte deficiency redox balance follicular stem cells melanocyte function keratinocyte function ginseng melanosomes microneedles hyaluronic acid nanoparticles micelles stem cells
Studysummary This study developed a hydrogel microneedle system combining ginseng-derived exosomes and biomimetic nanoparticles to address oxidative stress, inflammation, and melanocyte deficiency in vitiligo, showing significant repigmentation in mice within 3 weeks by enhancing melanocyte protection and keratinocyte proliferation.
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