Silk Fibroin-Based Hydrogel Microneedles Deliver Alpha-MSH to Promote Melanosome Delivery for Vitiligo Treatment

    April 2023 in “ ACS Biomaterials Science & Engineering ”
    Shu-bin Chong, Chengxiu Wei, Longbao Feng, Rui Guo
    TLDR Silk fibroin microneedles can effectively treat vitiligo by promoting skin pigmentation.
    Silk fibroin-based hydrogel microneedles have been developed to deliver α-MSH directly to the epidermis, offering a promising treatment for vitiligo by protecting melanocytes, promoting dendrite extension, and enhancing melanosome transfer. This method up-regulates melanogenesis-related factors and increases the number of hair follicle stem cells with good proliferative activity, presenting a novel approach to address the depigmentation characteristic of vitiligo.
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