Silk Fibroin-Based Hydrogel Microneedles Deliver Alpha-MSH to Promote Melanosome Delivery for Vitiligo Treatment

    April 2023 in “ ACS Biomaterials Science & Engineering ”
    Shu-bin Chong, Chengxiu Wei, Longbao Feng, Rui Guo
    TLDR Silk fibroin microneedles can effectively treat vitiligo by promoting skin pigmentation.
    The study explores the use of silk fibroin-based hydrogel microneedles for delivering α-MSH to treat vitiligo, a skin condition characterized by depigmentation. These microneedles facilitate the direct delivery of α-MSH to the epidermis, which aids in protecting melanocytes, extending melanocytic dendrites, and transferring melanosomes. This process up-regulates the expression of melanogenesis-related factors and increases the number of hair follicle stem cells with good proliferative activity. The slow-release mechanism of α-MSH through these microneedles presents a novel approach for vitiligo treatment.
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