Treatment with Injectable Platelet-Rich Fibrin in a Rat Model of Melasma

October 2023 in “ European journal of dermatology/EJD. European journal of dermatology ”

Ze-Xu Liang, Meng-Ru Wang, Xinjian Xiang, Yu Zhou

injectable platelet-rich fibrin I-PRF melasma intradermal injections melanin epidermis oxidative stress PRF

TLDR Injectable platelet-rich fibrin can safely and effectively treat melasma.

The study evaluated the efficacy of injectable platelet-rich fibrin (I-PRF) in treating melasma using a rat model. Sprague Dawley rats with melasma were divided into experimental and control groups, with the experimental group receiving weekly intradermal injections of I-PRF and the control group receiving saline. After four weeks, the results showed that I-PRF inhibited melanin production in the epidermis and reduced oxidative stress damage in the cortex, leading to an improvement in melasma. The study concluded that I-PRF is a safe and cost-effective treatment for melasma.

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research Melasma in Men

1 citations, January 2015 in “Journal of Pigmentary Disorders”

Treating melasma in men is difficult, especially for the deeper skin layers, and may need more than just topical treatments.