Unveiling the Potential of Inorganic Nanoparticle-Based Scaffolds in Wound Healing: Advances in Antimicrobial and Regenerative Strategies

Inorganic nanoparticle-based scaffolds show promise in enhancing wound healing by providing localized antimicrobial action and supporting tissue regeneration. These scaffolds leverage the unique properties of nanoparticles, such as high surface area and controlled ion release, to inhibit biofilm formation and promote processes like immunomodulation and angiogenesis. The review discusses various fabrication strategies, including electrospun nanofibers and 3D-printed constructs, and their impact on scaffold properties. While significant clinical progress has been made, challenges remain in optimizing ion release and scaffold stability. The review emphasizes the potential of these scaffolds in advanced wound care and suggests future directions for their design and clinical application.