A Sandwich-Like Silk Fibroin/Polysaccharide Composite Dressing with Continual Biofluid Draining for Wound Exudate Management

The study presents a novel sandwich-like silk fibroin/polysaccharide composite dressing designed for effective wound exudate management. This dressing features a three-layer structure: a hydrophobic silk fibroin membrane, a superabsorbent chitosan-konjac glucomannan sponge, and a graphene oxide-soaked hydrophilic cellulose acetate membrane. The design facilitates continuous exudate drainage, maintaining optimal wound moisture and accelerating healing. Animal experiments demonstrated superior wound healing, with wounds reducing to 24.8% of their original size compared to 28.5% for commercial dressings and 43.2% for controls. The dressing's effectiveness is attributed to its hierarchical porous structure, adjustable hydrophilicity, and the photothermal effect of graphene oxide, suggesting its potential as a next-generation clinical dressing.