Optimization of Menthol-Loaded Nanocapsules for Skin Application Using the Response Surface Methodology

    July 2019 in “ Journal of drug delivery science and technology ”
    Bancha Yingngam, Abhiruj Chiangsom, Paranda Pharikarn, Kantaphong Vonganakasame, Virawanan Kanoknitthiran, Wandee Rungseevijitprapa, Chutinun Prasitpuriprecha
    Image of study
    TLDR Researchers created better skin-application menthol capsules that are stable, safe, and penetrate the skin quickly.
    In 2019, researchers optimized menthol-loaded nanocapsules for skin application using response surface methodology. The study aimed to improve menthol's solubility and stability by encapsulating it in lipid-core nanocapsules. The optimal formulation contained 150 mg of menthol, 84 mg of poly(ε-caprolactone), and 125 mg of poloxamer 188, resulting in nanocapsules with good physicochemical characteristics, high entrapment efficiency (93.44% to 98.99%), and rapid skin penetration. The nanocapsules were non-irritating and non-toxic as shown by tests on human skin cells and a hen's egg chorioallantoic membrane assay. The particle size of the nanocapsules ranged from 122 to 354 nm, with a polydispersity index indicating homogeneity, and they remained stable for at least 90 days. Advanced imaging techniques confirmed the spherical shape and smooth surface of the nanocapsules, and they allowed for deeper penetration of menthol into the skin compared to non-encapsulated menthol. The study concluded that the optimized nanocapsules could be a promising alternative for topical application and cosmetotextiles.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 24 results

      community Seriously confused about minoxidil's method of action

      in Minoxidil  6 upvotes 2 years ago
      The conversation discusses confusion about how Minoxidil promotes hair growth compared to other substances like Menthol, which have similar actions. The user mentions personal positive results with peppermint oil extract and is currently trying L-citrulline for its vasodilation effects.

      community Hair Regrowth with Novel Hemp Extract - anyone seen this??

      in Research/Science  18 upvotes 2 months ago
      A user discusses a novel hemp extract for hair regrowth, which showed superior results to finasteride and minoxidil. The formula includes CBD, CBDV, THCV, delta 9 THC, cannabigerol, and cannabinol, combined with menthol, peppermint oil, ethanol, Emu oil, HFA 134A propellant, and dimethicone.

      community Is this hemp inflammation cream good for hair loss

      in Product  3 upvotes 2 months ago
      A user discusses using a hemp inflammation cream for hair loss, noting it contains aloe vera, hemp extract, rosemary oil, glycerin, emu oil, menthol, and MSM, which are beneficial for hair loss. They consider using the cream instead of making their own topical treatment.

      community Making topical finasteride solution

      in Finasteride/Dutasteride  1 upvotes 7 months ago
      The user has been mixing finasteride with stemoxydine for hair loss and is considering switching to a less expensive product with a different ingredient list. They are questioning if the new product's higher water content compared to alcohol will affect the finasteride's solubility.