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The document concludes that current treatments for androgenic alopecia are not fully effective, but new therapies like botulinum toxin and PRP show promise, and future gene therapy could be beneficial.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Testosterone works in different ways, including direct interaction with its receptor, conversion to other hormones for specific effects on genitalia, hair, bones, and muscle, and changes in body fat and sexual function when low.

Parthenolide promotes hair growth in mice and may influence pathways related to male pattern baldness.

Finasteride reduces hair follicle cell death in androgenetic alopecia.

The conclusion is that small hair follicles cause baldness in macaques, and treatments like antiandrogens and minoxidil can prevent hair loss and promote regrowth.

Free fatty acids may increase androgen production, potentially contributing to polycystic ovary syndrome.

Androgenic alopecia causes hair thinning, and treatments include minoxidil, finasteride, and light therapy.

Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Male hormones worsen kidney transplant damage, but blocking them helps.

Male rats have more somatostatin neurons than females due to testosterone converting to estrogen during early development.

Cimicifuga racemosa extract may help prevent and treat prostate issues by inhibiting 5α-reductase.

Diet, especially dairy and high-sugar foods, can cause acne.

Different treatments for skin conditions were found to be effective and generally safe, with biologics recommended as the first choice for generalized pustular psoriasis.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Higher BPA levels may be linked to idiopathic hyperandrogenemia in women.

Young women with diffuse hair loss may have low SHBG levels, which could lead to more active testosterone and contribute to their hair loss.

People with hair loss often have lower levels of zinc and copper in their blood.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Alopecia patients have less GPER-1, which might affect hair loss.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

Finasteride potentially treats hair loss by reducing DHT production.

High MUC-18/MCAM levels in blood indicate a worse outlook for melanoma patients.

Lower SHBG levels may increase the risk of PCOS.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Clinical signs of excess male hormones and actual hormone levels in the blood do not always match in women with polycystic ovary syndrome.

Taking 1mg finasteride tablets for 6 months can lower good cholesterol (HDL) and raise triglycerides in men with hair loss.

Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.