TLDR Finasteride is a safe and effective long-term treatment for prostate enlargement, reducing prostate volume and related symptoms.
Finasteride, a 5α-reductase inhibitor, has been shown to be a safe and effective treatment for benign prostatic hyperplasia (BPH). Two multicenter placebo-controlled studies demonstrated that after 12 months of treatment with 5 mg finasteride daily, prostate volume, dihydrotestosterone (DHT) and prostate-specific antigen (PSA) levels were reduced, while maximum urinary flow rates and symptom scores improved. Finasteride was well-tolerated. A long-term study involving approximately half of the patients who were initially treated with 5 mg finasteride for 3 years confirmed the continued safety and efficacy of the drug in the treatment of symptomatic BPH.
187 citations
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January 1994 in “The New England Journal of Medicine” Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.
1040 citations
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October 1992 in “The New England Journal of Medicine” Finasteride effectively treats BPH but may increase sexual dysfunction risk.
55 citations
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March 1990 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.
June 2019 in “Journal of Drug Delivery and Therapeutics” Finasteride effectively treats hair loss and prostate issues with minimal side effects.
18 citations
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January 2011 in “Bioorganic & Medicinal Chemistry Letters” New hybrid compound found to effectively prevent hair loss.
4 citations
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August 2010 in “Acta Biologica Hungarica” New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
60 citations
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December 1998 in “Clinical Pharmacology & Therapeutics” Both drugs lower DHT levels, with GI198745 being more effective.
136 citations
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March 1996 in “Journal of the American Chemical Society” Finasteride effectively blocks enzyme causing male pattern baldness.
30 citations
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August 1992 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride doesn't affect hormone levels in normal men.