Diagnosis of an Indistinct Leydig Cell Tumor by Positron Emission Tomography-Computed Tomography

    January 2019 in “ Obstetrics & gynecology science ”
    Jinkyoung Kong, Yoo Mee Park, Young Sik Choi, SiHyun Cho, Byung Seok Lee, Joo Hyun Park
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    TLDR A PET-CT scan successfully located a hard-to-find Leydig cell tumor in a woman with hormonal symptoms.
    In 2019, a 51-year-old female patient with symptoms of hirsutism and voice thickening was diagnosed with a Leydig cell tumor, which was initially elusive to detection through transvaginal sonography, CT, and MRI. Elevated levels of testosterone, 5a-dihydrotestosterone, and DHEA suggested an androgen-secreting tumor, but it was only with the use of 18F-fluorodeoxyglucose PET-CT that the tumor was localized in the right adnexa. Following a total laparoscopic hysterectomy with bilateral salpingo-oophorectomy, the Leydig cell tumor was pathologically confirmed within the right ovary. The patient's hormone levels normalized, and the virilization symptoms significantly improved after a 3-month follow-up.
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