Features of Steroidogenesis and Arterial Hypertension in Men in Different Types of Physiological Male Hyperandrogenism
May 2023
in “
Problems of Endocrinology
”
New to Estradiol? There is a guide in the encyclopedia. Read the guide → Studysummary This study observed that "physiological" hyperandrogenism due to elevated total testosterone was associated with a 23.5% incidence of arterial hypertension, unlike hyperandrogenism due to elevated DHT levels. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated steroidogenesis and arterial hypertension in men with "physiological" hyperandrogenism, comparing those with elevated total testosterone (n=34) and elevated dihydrotestosterone (DHT) (n=66). It found that no cases of arterial hypertension were observed in men with elevated DHT levels, while 23.5% of men with elevated total testosterone had arterial hypertension, characterized by increased blood pressure in the early morning. Men with testosterone hyperandrogenism showed increased levels of 17-hydroxypregnenolone, 17-hydroxyprogesterone, and androstenedione, and those with arterial hypertension had lower estradiol levels compared to those without hypertension.
