Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This article discusses the documented benefits of finasteride for managing benign prostatic hyperplasia, noting the need for monitoring due to its effects on serum PSA levels; it reports no adverse impact on prostate cancer detection.

This study evaluated androgen-induced hair loss and anagen induction mouse models, finding that Minoxidil and Pyrilutamide significantly promoted hair growth by decreasing androgen receptor protein levels and enhancing the Wnt/β-Catenin signaling pathway, supporting their use in studying novel treatments for androgenetic alopecia.

In this study, teicoplanin significantly improved hair regrowth and follicle size in mice with dihydrotestosterone-induced androgenetic alopecia, suggesting its potential as a treatment option for hair loss due to its ability to enhance cell proliferation and decrease androgen receptor protein levels.

In this prospective study, researchers identified advanced age, androgenetic alopecia, high levels of lactate dehydrogenase and dihydrotestosterone, and low levels of adenosine triphosphate as independent risk factors for posttransplant telogen effluvium, offering insights for optimizing surgical strategies to reduce PTE risk.

This study found that combining fire needle therapy with DHT treatment over eight weeks improved lesion severity, scar symptoms, quality of life, and reduced serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.

This study observed that in spontaneously hypertensive rats, testosterone's effects on endothelium-dependent vasodilation involved reduced nitric oxide levels, increased oxidative stress, and greater reliance on endothelium-dependent hyperpolarization, with variations in these responses noted when testosterone was combined with either anastrozole or finasteride.

In this study, researchers successfully established immortalized human frontal and occipital scalp dermal papilla cell lines from androgenetic alopecia patients, observing distinct gene expression, androgen receptor levels, and hair follicle growth effects between these regions, which may help advance hair loss research and therapeutic development.

This animal study found that finasteride, a 5-alpha reductase type 2 inhibitor, decreased dihydrotestosterone levels and c-Fos protein activation in the rat brain, but these effects may diminish after discontinuing the drug.

This study suggests that oleanolic acid may promote hair growth in mice with testosterone-induced androgenetic alopecia by activating the Wnt/β-catenin pathway and influencing various molecular levels.

This study found that supraphysiological doses of testosterone alter endothelial relaxation pathways in hypertensive rats, with varied contributions from nitric oxide, prostanoids, and endothelium-derived hyperpolarizing factors, influenced by estrogen and dihydrotestosterone levels.

This study found that chronic administration of dutasteride in rats did not affect spermatogenesis or oxidative stress in the testes, although it altered hormone levels.

This study suggests that the elevated stress hormone response in adolescent male rats may involve increased conversion of testosterone to estradiol at the adrenal cortex level.

This review discusses testosterone replacement therapy, highlighting that most studies report no increased myocardial infarction risk when the therapy is properly administered with controlled hormone levels; it calls for careful consideration despite insurance coverage challenges.

This study found that testosterone therapy improved physical performance, strength, lean body mass, and serum cholesterol in older men with low testosterone levels, with or without the addition of finasteride.

This study found that women with PCOS have higher activity of the enzyme 5alpha-reductase, which may contribute to their elevated androgen levels.

This study found that intradermal injection of a specially designed RNA molecule, cp-asiAR, successfully reduced androgen receptor levels and promoted hair growth in a mouse model of androgenetic alopecia, while also improving hair follicle characteristics in ex vivo human scalp tissues without significant toxicity.

This study observed that using only a 5 alpha-reductase inhibitor was ineffective for treating androgen-dependent hair loss in women, possibly due to differing copper levels influencing enzyme activity.

This research observed that oral testosterone replacement therapy significantly increases cardiovascular risk, while effects of injected or transdermal therapy on cardiovascular risk were not significant, prompting further investigation into these methods.

Photobiomodulation helps protect hair follicle cells from damage caused by DHT.

This study suggests that male pattern baldness is primarily caused by heat stress in the brain rather than DHT toxicity, and personal experiments with menthol cooling have shown significant reduction in hair loss.

This study found that both cyproterone acetate alone and combined with ethinyl oestradiol reduced androgen levels and slightly increased SHBG binding in women with hirsutism, but showed no difference in hair regrowth rate between the treatments.

This study found that three genetic loci, including the newly identified JMJD1C, are associated with circulating testosterone and dihydrotestosterone levels, explaining a small portion of their variance in European men.

This study concluded that steroid deficiencies were significantly more severe in men with panhypopituitarism than in those with isolated gonadotropin deficiency.

Finasteride helps prevent hair loss and promote hair growth.

This study indicates that the normal human prostate is not a major contributor to circulating blood DHT concentrations in androgen-deficient patients receiving testosterone replacement therapy.

This study suggests that alterations in copper metabolism may play a key role in the development of androgenetic alopecia in women, presenting potential targets for treatment strategies.

This review discusses the effects and potential benefits of finasteride in treating hirsutism and androgenetic alopecia but reports no new clinical results.

IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.

This study found that low serum testosterone and elevated serum oestrone in men with cirrhosis are associated with worse liver disease and adverse health outcomes, suggesting oestrone as a potential ill health marker.

This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.