Regulation of Masculinization: Androgen Signaling for External Genitalia Development

    April 2018 in “ Nature Reviews Urology ”
    Shoko Matsushita, Kentaro Suzuki, Aki Murashima … Gen Yamada
    Studysummary This review discusses the molecular mechanisms of masculinization involving androgen signaling and their roles in male embryonic development and conditions like hypospadias and prostate cancer, and reports no clinical results.
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    Research cited in this study 3

    1. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    2. Systematic Analyses of Murine Masculinization Processes Based on Genital Sex Differentiation Parameters Development Growth & Differentiation · 2015
    3. Disruption of the Temporally Regulated Cloaca Endodermal β-Catenin Signaling Causes Anorectal Malformations Cell death and differentiation · 2014

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