Association of CYP11A Gene with Polycystic Ovarian Syndrome Patients in Lahore, Pakistan

January 2025 in “ Pakistan Journal of Health Sciences ”

A. Jagannadha Rao, A. Vijaya Rao, Zubaidah Abdul Wahab, Hafiza Kashaf Qudsia, Rafia Javed

Cyp11a gene polycystic ovary syndrome PCOS anovulatory PCOS di-hydro-testosterone DHT Cyp11a1 a-PCOS

Studysummary This study found a weak association between Cyp11a1 gene variation and polycystic ovary syndrome, with higher di-hydro-testosterone levels observed in individuals with the syndrome and anovulatory PCOS compared to controls.

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This study investigated the association between the Cyp11a gene and polycystic ovary syndrome (PCOS) in Lahore, Pakistan, using a sample of 75 participants. The results showed that the Cyp11a1 gene variation (SNP rs6495096) was present in both PCOS patients and controls, with an odds ratio of 1.199, suggesting a weak relationship between this gene variation and PCOS. Additionally, di-hydro-testosterone levels were higher in both PCOS and anovulatory PCOS (a-PCOS) groups compared to controls, with mean values of 278.18, 260.97, and 190.83, respectively. The study concludes that while there is a presence of the Cyp11a1 gene variation in PCOS, the relationship is weak, and elevated di-hydro-testosterone levels are observed in PCOS and a-PCOS groups.

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Research cited in this study

3 / 3 results

A Community-Based Cross-Sectional Study on Prevalence of Polycystic Ovarian Syndrome and Health-Related Quality of Life in Pakistani Females

research A Community-Based Cross-Sectional Study on Prevalence of Polycystic Ovarian Syndrome and Health-Related Quality of Life in Pakistani Females

August 2020 in “Research Square (Research Square)”

This study found that young females in Punjab, Pakistan, showed increased prevalence of PCOS symptoms, yet most were unaware of PCOS, suggesting a need for enhanced educational efforts.

research Hyperandrogenism in Polycystic Ovarian Syndrome and Role of CYP Gene Variants: A Review

49 citations , November 2019 in “Egyptian Journal of Medical Human Genetics”

This review discusses the role of CYP gene polymorphisms in exacerbating hyperandrogenism in women with PCOS and reports no clinical results; further validation of this hypothesis is needed.

research Clinical and Biochemical Characteristics in PCOS Women With Menstrual Abnormalities

3 citations , December 2016 in “PubMed”

This study found that PCOS patients with menstrual disorders exhibited hormonal changes and higher fasting glucose levels, despite no significant differences in insulin resistance markers.