This study investigated the association between the Cyp11a gene and polycystic ovary syndrome (PCOS) in Lahore, Pakistan, using a sample of 75 participants. The results showed that the Cyp11a1 gene variation (SNP rs6495096) was present in both PCOS patients and controls, with an odds ratio of 1.199, suggesting a weak relationship between this gene variation and PCOS. Additionally, di-hydro-testosterone levels were higher in both PCOS and anovulatory PCOS (a-PCOS) groups compared to controls, with mean values of 278.18, 260.97, and 190.83, respectively. The study concludes that while there is a presence of the Cyp11a1 gene variation in PCOS, the relationship is weak, and elevated di-hydro-testosterone levels are observed in PCOS and a-PCOS groups.
August 2020 in “Research Square (Research Square)” Many young women in Punjab, Pakistan, show symptoms of PCOS and have a lower quality of life, but they are not aware of the condition.
49 citations
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November 2019 in “Egyptian Journal of Medical Human Genetics” Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.
3 citations
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December 2016 in “PubMed” Menstrual abnormalities in PCOS women may not greatly affect their metabolic and hormonal profile.
117 citations
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May 2017 in “Human Reproduction Update” The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.
45 citations
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May 2022 in “Biomedicines” Analyzing follicular fluid can help predict and improve outcomes for women with PCOS undergoing fertility treatments.
November 2016 in “Elsevier eBooks” Genetic mutations can affect female sexual development, requiring personalized medical care.
October 2023 in “IntechOpen eBooks” Genes and epigenetic changes are important in the development of Polycystic Ovary Syndrome.
249 citations
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November 2003 in “Clinical endocrinology” Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.
