Association of CYP11A Gene with Polycystic Ovarian Syndrome Patients in Lahore, Pakistan

This study investigated the association between the Cyp11a gene and polycystic ovary syndrome (PCOS) in Lahore, Pakistan, using a sample of 75 participants. The results showed that the Cyp11a1 gene variation (SNP rs6495096) was present in both PCOS patients and controls, with an odds ratio of 1.199, suggesting a weak relationship between this gene variation and PCOS. Additionally, di-hydro-testosterone levels were higher in both PCOS and anovulatory PCOS (a-PCOS) groups compared to controls, with mean values of 278.18, 260.97, and 190.83, respectively. The study concludes that while there is a presence of the Cyp11a1 gene variation in PCOS, the relationship is weak, and elevated di-hydro-testosterone levels are observed in PCOS and a-PCOS groups.